119860-09-2

Basic information

• Product Name: [4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester
• CAS NO: 119860-09-2
• Molecular Weight: 409.39
• Mol File: 119860-09-2.mol

Chemical Properties

• CAS DataBase Reference: [4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester(119860-09-2)
• EPA Substance Registry System: [4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester(119860-09-2)

Safety Data

• Hazardous Substances Data: 119860-09-2(Hazardous Substances Data)

Upstream product

• 119860-08-1 N⁴-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)-1,4-pentanediamine 
• 142035-73-2 (R,S)-α-benzyloxycarbonylamino-3-(4-nitrophenyl)propionic acid methyl ester 
• 119920-86-4 (R,S)-4-benzyloxycarbonylamino-5-(4-nitrophenyl)-2,2-difluoro-3-hydroxypentanoic acid ethyl ester 
• 119860-38-7 (R,S)-α-benzyloxycarbonylamino-3-(4-nitrophenyl)propanal 
• 119860-39-8 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide 
• 119372-54-2 (S)-4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitro-phenyl)-pentanoic acid ethyl ester 
• 20299-41-6 (S)-2-Benzyloxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 119372-44-0 [(S)-1-Formyl-2-(4-nitro-phenyl)-ethyl]-carbamic acid benzyl ester 
• 119351-64-3 [(S)-3-Carbamoyl-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-propyl]-carbamic acid benzyl ester 

Downstream Products

• 119860-12-7 [4-(5-Acetylamino-2-amino-4,4-difluoro-3-hydroxy-pentyl)-phenyl]-carbamic acid tert-butyl ester 
• 119885-17-5 N₁-Acetyl-N₄-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-aminophenyl)-1,4-pentanediamine 
• 119860-11-6 N¹-acetyl-N⁴-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5(4-tert-butoxycarbonylamino-phenyl)-1,4-pentane diamine 
• 173918-65-5 (N-tert-butoxycarbonyl-D-phenylalanyl)-N-<4-acetylamino-1-<(4-tert-butoxycarbonylaminophenyl)methyl>-3,3-difluoro-2-hydroxybutyl>-L-prolinamide 
• 173918-66-6 (N-benzyloxycarbonyl-D-phenylalanyl)-N-<4-acetylamino-3,3-difluoro-2-hydroxy-1-<4((((benzyloxycarbonylamino)benzyloxycarbonylimino)methyl)amino)phenyl>methyl>butyl-L-prolinamide 
• 173918-66-6 C₅₂H₅₅F₂N₇O₁₀ 
• 138875-65-7 (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride 
• 119860-10-5 N¹-acetyl-N⁴-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)-1,4-pentanediamine 
• 119860-08-1 N⁴-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)-1,4-pentanediamine 
• 119351-74-5 [(S)-4-tert-Butoxycarbonylamino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester 

Relevant articles and documents

Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright

General Synthesis of Polyfunctionalized Fluoromethyleneketone Retroamides as Potential Inhibitors of Thrombin

Synthesis of polyfunctionalized fluoromethyleneketone retroamides is described.A potential inhibitor of human Thrombin has been prepared through a Reformatsky type condensation from N-protected p-NO2 phenylalaninal.The reaction conditions are applicable t

A CONVENIENT SYNTHESIS OF &α',&β-DIAMINO- &α,&α-DIFLUOROKETONES, NEW DIPEPTIDE ISOSTERES

A convenient and versatile synthesis of α',β-diamino-α,α-difluoroketones is described.These compounds represent a new class of true dipeptide isosteres useful for the design of serine protease inhibitors.