3-O-octadecyl sn-glycero(1)phosphocholine

Base Information

• Chemical Name: 3-O-octadecyl sn-glycero(1)phosphocholine
• CAS No.: 80736-28-3
• Molecular Formula: C₂₆H₅₆NO₆P
• Molecular Weight: 509.707
• Mol file: 80736-28-3.mol

Synonyms:

Chemical Property of 3-O-octadecyl sn-glycero(1)phosphocholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-octadecyl sn-glycero(1)phosphocholine

There total 15 articles about 3-O-octadecyl sn-glycero(1)phosphocholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-O-Benzyl-3-O-octadecyl-sn-glyceryl-1-phosphorylcholin (80736-27-2) → 3-O-octadecyl sn-glycero(1)phosphocholine (80736-28-3,34240-68-1)

Guidance literature:

With hydrogen; palladium; In ethanol; at 50 ℃; for 72h; under 760 Torr;

DOI:10.1248/cpb.33.572

Reference yield:

(R)-octadecylglycerol (10567-22-3) → 3-O-octadecyl sn-glycero(1)phosphocholine (80736-28-3,34240-68-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 81 percent / pyridine / Ambient temperature

2: NaH / dimethylformamide / 80 °C

3: 1N HCl / dioxane / 90 °C

4: phosphorus oxychloride, Et₃N, pyridine / CHCl₃ / Ambient temperature

5: H₂ / PdO / methanol; H₂O / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; sodium hydride; triethylamine; trichlorophosphate; trimethyleneglycol; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19820650339

Reference yield:

2-O-benzyl-3-O-octadecyl sn-glycerol (80459-31-0,89104-47-2) → 3-O-octadecyl sn-glycero(1)phosphocholine (80736-28-3,34240-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus oxychloride, Et₃N, pyridine / CHCl₃ / Ambient temperature

2: H₂ / PdO / methanol; H₂O / Ambient temperature

With pyridine; hydrogen; triethylamine; trichlorophosphate; trimethyleneglycol; In methanol; chloroform; water;

DOI:10.1002/hlca.19820650339

upstream raw materials:

2-O-Benzyl-3-O-octadecyl-sn-glyceryl-1-phosphorylcholin

(R)-octadecylglycerol

n-octadecyl p-toluenesulfonate

3-O-Octadecyl-1-O-trityl-sn-glycerin

Downstream raw materials:

Ro 15-4454