N¹-(4-acetylphenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride

Base Information

• Chemical Name: N¹-(4-acetylphenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride
• CAS No.: 1375736-82-5
• Molecular Formula: C₂₁H₂₆N₄O₄S*ClH
• Molecular Weight: 466.989

Synonyms:

Chemical Property of N¹-(4-acetylphenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride

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Technology Process of N¹-(4-acetylphenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride

There total 4 articles about N¹-(4-acetylphenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

C11H19N3OS (1375737-18-0) + N-(4-Acetyl-phenyl)-oxalamic acid (6345-10-4) → N1-(4-acetylphenyl)-N2-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride (1375736-82-5)

Guidance literature:

C₁₁H₁₉N₃OS; N-(4-Acetyl-phenyl)-oxalamic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;

With hydrogenchloride;

DOI:10.1021/jm3002247

Reference yield: 42.0%

→ N1-(4-acetylphenyl)-N2-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride (1375736-82-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 6h;

Reference yield:

p-aminobenzophenone (99-92-3) → N1-(4-acetylphenyl)-N2-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride (1375736-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: water; sodium hydroxide / ethanol

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/jm3002247

upstream raw materials:

C₁₁H₁₉N₃OS

N-(4-Acetyl-phenyl)-oxalamic acid

N-(4-acetyl-phenyl)-ethyl oxalate

p-aminobenzophenone

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