m-PEG3-S-Acetyl

Base Information

• Chemical Name: m-PEG3-S-Acetyl
• CAS No.: 857284-78-7
• Molecular Formula: C₉H₁₈O₄S
• Molecular Weight: 222.306
• Mol file: 857284-78-7.mol

Synonyms:

Chemical Property of m-PEG3-S-Acetyl

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

m-PEG3-S-Acetyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG3-S-Acetyl is a PEG linker with a sulfur-acetyl end group. The sulfur acetyl group can be deprotected to generate thiol groups. After the formation of the thiol group, it is able to react with maleimides, disulfides, haloacteamides and other thiols. The hydrophilic PEG linker increases the solubility of the compound in aqueous media.

Technology Process of m-PEG3-S-Acetyl

There total 7 articles about m-PEG3-S-Acetyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) + potassium thioacetate (10387-40-3) → S-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)ethanethioate (857284-78-7)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol202051y

Reference yield:

triethylene glucol monomethyl ether (112-35-6,95507-80-5) + methanesulfonyl chloride (124-63-0) + potassium thioacetate (10387-40-3) → S-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)ethanethioate (857284-78-7)

Guidance literature:

triethylene glucol monomethyl ether; methanesulfonyl chloride; With triethylamine;

potassium thioacetate;

Reference yield:

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → S-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)ethanethioate (857284-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane

2: acetone / 50 °C

With dmap; triethylamine; In dichloromethane; acetone;

DOI:10.1021/la302168g

upstream raw materials:

triethylene glucol monomethyl ether

methanesulfonyl chloride

potassium thioacetate

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

Downstream raw materials:

C₃₃H₅₂O₆SSi₄

2-<2-(2-methoxyethoxy)ethoxy>ethylthiol

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