4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester

Base Information

• Chemical Name: 4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester
• CAS No.: 879562-26-2
• Molecular Formula: C29H28N6O5
• Molecular Weight: 540.579
• Mol file: 879562-26-2.mol

Synonyms:Olmesartan medoxomil impurity I

Chemical Property of 4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester

Chemical Property:

• Boiling Point: 774.0±70.0 °C(Predicted)
• PKA: 4.16±0.10(Predicted)
• PSA: 141.93000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 4.97570

Purity/Quality:

98%,99%, ^*data from raw suppliers

DehydroOlmesartanMedoxomil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dehydro Olmesartan Medoxomil (Olmesartan EP Impurity C) is an intermediate used in the process for purifying Olmesartan Medoxomil. Olmesartan medoxomil impurity I is an intermediate used in the process for purifying Olmesartan Medoxomil.

Technology Process of 4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester

There total 4 articles about 4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C48H42N6O5 (1227626-51-8) → (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate (879562-26-2)

Guidance literature:

With acetic acid; In water; at 55 - 60 ℃;

DOI:10.3998/ark.5550190.0011.224

Reference yield:

olmesartan medoxomil (144689-63-4) → (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate (879562-26-2)

Guidance literature:

olmesartan medoxomil; With sulfuric acid; In ISOPROPYLAMIDE; at 100 ℃; for 2.5h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; ISOPROPYLAMIDE; water; at 40 ℃; pH=4.2;

Reference yield:

C29H29ClN6O5 → (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate (879562-26-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

C₄₈H₄₂N₆O₅

olmesartan medoxomil

olmesartan

Downstream raw materials:

1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Refernces

• 1、 -. "METHOD FOR PRODUCING OLMESARTAN MEDOXOMIL". Page/Page column 10-11. . Retrieved 2012/03/26.