Methimepip

Base Information

Chemical Name:Methimepip
CAS No.:151070-80-3
Molecular Formula:C₁₀H₁₇N₃
Molecular Weight:179.265
Hs Code.:
UNII:259YSH2WL6
ChEMBL ID:CHEMBL175782
DSSTox Substance ID:DTXSID501027200
Nikkaji Number:J3.149.554G
Pharos Ligand ID:AYJ3DQZQPQWP
Wikidata:Q6593527
Wikipedia:Methimepip
Mol file:151070-80-3.mol

Synonyms:4-(1H-imidazol-4-ylmethyl)-1-methylpiperidine;methimepip

Suppliers and Price of Methimepip

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methimepip
10mg
$ 560.00

TRC
Methimepip
5mg
$ 345.00

American Custom Chemicals Corporation
METHIMEPIP 95.00%
50MG
$ 1230.95

American Custom Chemicals Corporation
METHIMEPIP 95.00%
10MG
$ 709.46

Total 4 raw suppliers

Chemical Property of Methimepip

Chemical Property:

Boiling Point:345.2±15.0 °C(Predicted)
PKA:14?+-.0.10(Predicted)
Density:1.071±0.06 g/cm3(Predicted)
Storage Temp.:Desiccate at RT
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:179.142247555
Heavy Atom Count:13
Complexity:152

Purity/Quality:

95% ^*data from raw suppliers

Methimepip ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCC(CC1)CC2=CN=CN2
Uses Methimepip is a selective histamine H3 receptor agonist and a derivative of Immepip (I490000).

Technology Process of Methimepip

There total 6 articles about Methimepip which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 817636-73-0
4-(imidazol-4-ylmethyl)piperidine-1-carboxylic acid tert-butyl ester

: 151070-80-3
methimepip

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / aq. HBr / 2 h / 80 °C

2: aq. HCO₂H / methanol / 6 h / Heating

With formic acid; hydrogen bromide; In methanol;
DOI:10.1021/jm049475h

Reference yield:

: 817636-74-1
4-[4-(4-methylbenzenesulfonyl)-4,5-dihydrooxazol-5-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester

: 151070-80-3
methimepip

Guidance literature:: Multi-step reaction with 3 steps

1: 13.7 g / NH₃ / ethanol / 16 h / 90 - 110 °C

2: 65 percent / aq. HBr / 2 h / 80 °C

3: aq. HCO₂H / methanol / 6 h / Heating

With formic acid; ammonia; hydrogen bromide; In methanol; ethanol;
DOI:10.1021/jm049475h

Reference yield:

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 151070-80-3
methimepip

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / Et₃N / CHCl₃ / 17 h

2: 90 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

3: NaCN / ethanol / 2 h

4: 13.7 g / NH₃ / ethanol / 16 h / 90 - 110 °C

5: 65 percent / aq. HBr / 2 h / 80 °C

6: aq. HCO₂H / methanol / 6 h / Heating

With formic acid; oxalyl dichloride; sodium cyanide; ammonia; hydrogen bromide; dimethyl sulfoxide; triethylamine; In methanol; ethanol; dichloromethane; chloroform; 2: Swern oxidation;
DOI:10.1021/jm049475h