Technology Process of Methimepip
There total 6 articles about Methimepip which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 65 percent / aq. HBr / 2 h / 80 °C
2: aq. HCO2H / methanol / 6 h / Heating
With
formic acid; hydrogen bromide;
In
methanol;
DOI:10.1021/jm049475h
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 13.7 g / NH3 / ethanol / 16 h / 90 - 110 °C
2: 65 percent / aq. HBr / 2 h / 80 °C
3: aq. HCO2H / methanol / 6 h / Heating
With
formic acid; ammonia; hydrogen bromide;
In
methanol; ethanol;
DOI:10.1021/jm049475h
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / Et3N / CHCl3 / 17 h
2: 90 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -60 - 20 °C
3: NaCN / ethanol / 2 h
4: 13.7 g / NH3 / ethanol / 16 h / 90 - 110 °C
5: 65 percent / aq. HBr / 2 h / 80 °C
6: aq. HCO2H / methanol / 6 h / Heating
With
formic acid; oxalyl dichloride; sodium cyanide; ammonia; hydrogen bromide; dimethyl sulfoxide; triethylamine;
In
methanol; ethanol; dichloromethane; chloroform;
2: Swern oxidation;
DOI:10.1021/jm049475h
