Technology Process of (S)-N-Boc-5,5,5,5,5,5-Hexafluoroleucine
There total 4 articles about (S)-N-Boc-5,5,5,5,5,5-Hexafluoroleucine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate;
In
N,N-dimethyl-formamide;
for 18h;
DOI:10.1021/ol015567e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / PPh3 / diethyl ether / 72 h / -78 - 20 °C
2: 98 percent / H2 / 10percent Pd/C / ethanol
3: 80 percent / TsOH / methanol / 24 h / 20 °C
4: 75 percent / PDC / dimethylformamide / 18 h
With
dipyridinium dichromate; hydrogen; toluene-4-sulfonic acid; triphenylphosphine;
10percent Pd/C;
In
methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
1: Wittig reaction;
DOI:10.1021/ol015567e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / H2 / 10percent Pd/C / ethanol
2: 80 percent / TsOH / methanol / 24 h / 20 °C
3: 75 percent / PDC / dimethylformamide / 18 h
With
dipyridinium dichromate; hydrogen; toluene-4-sulfonic acid;
10percent Pd/C;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ol015567e
