5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE

Base Information

• Chemical Name: 5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE
• CAS No.: 50907-31-8
• Molecular Formula: C7H4Cl2N4
• Molecular Weight: 215.042
• Hs Code.: 29339990
• Mol file: 50907-31-8.mol

Synonyms:1H-Tetrazole, 5-(2,6-dichlorophenyl)-;5-(2,6-Dichlorophenyl)-2H-1,2,3,4-tetraazole;

Chemical Property of 5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE

Chemical Property:

• Vapor Pressure: 1.32E-06mmHg at 25°C
• Melting Point: 202-204 °C
• Refractive Index: 1.641
• Boiling Point: 399.9 °C at 760 mmHg
• PKA: 3.27±0.10(Predicted)
• Flash Point: 227.9 °C
• PSA: 54.46000
• Density: 1.574 g/cm³
• LogP: 2.17350

Purity/Quality:

99% ^*data from raw suppliers

5-(2,6-Dichlorophenyl)-1H-tetrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39-27

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE

There total 7 articles about 5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-dichloro-benzonitrile (1194-65-6) → 2,6-dichloro-5-phenyl-1H-tetrazole (50907-31-8)

Guidance literature:

With sodium azide; gold; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c4ra13461c

Reference yield: 87.0%

2,6-dichloro-benzonitrile (1194-65-6) → 5-(2',6'-dichlorophenyl)tetrazole (50907-31-8)

Guidance literature:

With trimethylsilylazide; tetrabutyl ammonium fluoride; In neat (no solvent); at 85 ℃; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1016/j.bmcl.2016.02.078

Reference yield:

2,6-dichlorobenzaldoxime (25185-95-9) → 5-(2',6'-dichlorophenyl)tetrazole (50907-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / Heating

2: ammonium azide; ammonium chloride; lithium chloride / dimethylformamide / 24 h / 120 - 130 °C

With thionyl chloride; ammonium azide; ammonium chloride; lithium chloride; In N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmc.2005.04.075

upstream raw materials:

2,6-dichloro-benzonitrile

2,6-dichlorobenzaldoxime

2,6-dichlorobenzaldehyde

Downstream raw materials:

[3-(2,6-Dichloro-phenyl)-5-phenyl-[1,2,4]triazol-4-yl]-(4-nitro-phenyl)-amine

5-(2,6-dichlorophenyl)-2-methyltetrazole

5-(2,6-dichlorophenyl)-1-methyltetrazole

N-[1-[5-(2,6-Dichloro-phenyl)-tetrazol-2-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine

Refernces

• 1、 Kumar, Arvind,Kumar, Satyanand,Khajuria, Yugal,Awasthi, Satish Kumar. "A comparative study between heterogeneous stannous chloride loaded silica nanoparticles and a homogeneous stannous chloride catalyst in the synthesis of 5-substituted 1: H -tetrazole". . p. 75227 - 75233. Retrieved 2016/08/24.
• 2、 Pazik, Agnieszka,Skwierawska, Anna. "Selective detection of F- by chromogenic tetrazole receptor". . p. 189 - 198. Retrieved 2013/05/21.