3-IODO-TETRAHYDRO-FURAN

Base Information

• Chemical Name: 3-IODO-TETRAHYDRO-FURAN
• CAS No.: 121138-01-0
• Molecular Formula: C4H7IO
• Molecular Weight: 198.003
• Hs Code.: 2932190090
• Mol file: 121138-01-0.mol

Synonyms:3-IODO-TETRAHYDRO-FURAN

Chemical Property of 3-IODO-TETRAHYDRO-FURAN

Chemical Property:

• Boiling Point: 187.021 °C at 760 mmHg
• Flash Point: 66.908 °C
• PSA: 9.23000
• Density: 1.931 g/cm³
• LogP: 1.21030
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%, ^*data from raw suppliers

3-Iodotetrahydrofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Iodotetrahydrofuran is used to study transition-metal-free Heck-type reaction between alkenes and alkyl iodides enabled by light in water.

Technology Process of 3-IODO-TETRAHYDRO-FURAN

There total 4 articles about 3-IODO-TETRAHYDRO-FURAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-Hydroxytetrahydrofuran (453-20-3,84921-89-1,864447-89-2) → (RS)-3-iodotetrahydrofuran (121138-01-0)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; Reflux; Inert atmosphere;

Reference yield:

homoalylic alcohol (627-27-0) → 2-(iodomethyl)oxetane (121138-00-9) + (RS)-3-iodotetrahydrofuran (121138-01-0)

Guidance literature:

With iodonium(di-γ-collidine) perchlorate; In dichloromethane; at 20 ℃; for 1.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1055/s-1988-27731

Reference yield:

tetrahydro-3-furanyl tosylate (13694-84-3) → (RS)-3-iodotetrahydrofuran (121138-01-0)

Guidance literature:

With sodium iodide; In acetone; for 48h; Yield given; Heating;

DOI:10.1055/s-1988-27731

upstream raw materials:

homoalylic alcohol

tetrahydro-3-furanyl tosylate

3-Hydroxytetrahydrofuran

Downstream raw materials:

C₁₁H₁₃ClO₂

2-phenyl-3-(3-tetrahydrofuranyl)-2,1-borazaronaphthalene

Refernces

• 1、 Liu, Xian-Guan,Dong, Ci-Shuang,Li, Fei,Zhang, Bo. "Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an Aromatization-Dearomatization Strategy". supporting information. p. 4002 - 4007. Retrieved 2021/05/26.
• 2、 Chakraborty, Nirnita,Santra, Sougata,Kundu, Shrishnu Kumar,Hajra, Alakananda,Zyryanov, Grigory V.,Majee, Adinath. "Combination of NH2OH·HCl and NaIO4: an effective reagent for molecular iodine-free regioselective 1,2-difunctionalization of olefins and easy access of terminal acetals". . p. 56780 - 56788. Retrieved 2015/07/15.