4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine

Base Information

• Chemical Name: 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine
• CAS No.: 292858-47-0
• Molecular Formula: C₁₇H₁₅N₃O₅
• Molecular Weight: 341.323
• Mol file: 292858-47-0.mol

Synonyms:

Chemical Property of 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine

There total 3 articles about 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

6,7-dimethoxy-4-(3'-nitrophenyl)phtalazin-1(2H)-one (292858-36-7) + methyl iodide (74-88-4) → 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine (292858-47-0) + 6,7-dimethoxy-2-methyl-4-(3'-nitrophenyl)phtalazin-1(2H)-one (292858-40-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; toluene; for 2h; Heating;

Reference yield:

3,4-dihydro-6,7-dimethoxy-1-(3-nitrophenyl)-1H-isochromene (92774-39-5) → 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine (292858-47-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / aq. H₂SO₄; CrO₃ / acetone / 2 h / 20 °C

2: 83.6 percent / hydrazine hydrate / ethanol / Heating

3: 15 percent / NaH / tetrahydrofuran; toluene / 2 h / Heating

With chromium(VI) oxide; sulfuric acid; sodium hydride; hydrazine hydrate; In tetrahydrofuran; ethanol; acetone; toluene;

Reference yield:

4,5-dimethoxy-2-(3'-nitrobenzoyl)benzoic acid (92774-12-4) → 4-(3'-nitrophenyl)-1,6,7-trimethoxyphtalazine (292858-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 83.6 percent / hydrazine hydrate / ethanol / Heating

2: 15 percent / NaH / tetrahydrofuran; toluene / 2 h / Heating

With sodium hydride; hydrazine hydrate; In tetrahydrofuran; ethanol; toluene;

upstream raw materials:

6,7-dimethoxy-4-(3'-nitrophenyl)phtalazin-1(2H)-one

methyl iodide

4,5-dimethoxy-2-(3'-nitrobenzoyl)benzoic acid

3,4-dihydro-6,7-dimethoxy-1-(3-nitrophenyl)-1H-isochromene