4-(Chloromethyl)-1-methylpyrazole Hydrochloride

Base Information

• Chemical Name: 4-(Chloromethyl)-1-methylpyrazole Hydrochloride
• CAS No.: 154312-86-4
• Molecular Formula: C5H8Cl2N2
• Molecular Weight: 167.038
• Mol file: 154312-86-4.mol

Synonyms:4-(Chloromethyl)-1-methylpyrazole Hydrochloride

Chemical Property of 4-(Chloromethyl)-1-methylpyrazole Hydrochloride

Chemical Property:

• PSA: 17.82000
• LogP: 1.96090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(Chloromethyl)-1-methyl-1H-pyrazoleHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Useful building block for various synthetic routes. This product was previously listed as CBR01696.

Technology Process of 4-(Chloromethyl)-1-methylpyrazole Hydrochloride

There total 1 articles about 4-(Chloromethyl)-1-methylpyrazole Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1-methyl-1H-pyrazol-4-yl)-methanol (112029-98-8) → 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride (154312-86-4)

Guidance literature:

With thionyl chloride; In dichloromethane; at 25 - 30 ℃; for 2h; Inert atmosphere; Cooling;

Reference yield: 81.9%

4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride (154312-86-4) + C18H23NO3 → C23H29N3O3

Guidance literature:

C₁₈H₂₃NO₃; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 15 - 23 ℃; for 0.5h; Inert atmosphere;

4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 3h;

Reference yield:

4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride (154312-86-4) + 7-chloro-N-((1S,2S)-2-hydroxycyclohexyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide → 7-chloro-N-((1S,2S)-2-hydroxycyclohexyl)-1-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 168h;

upstream raw materials:

(1-methyl-1H-pyrazol-4-yl)-methanol

Downstream raw materials:

(1-methyl-1H-pyrazol-4-yl)acetonitrile