sarcosine-3-(4-methylbenzoate)-cyclosporin A

Base Information

• Chemical Name: sarcosine-3-(4-methylbenzoate)-cyclosporin A
• CAS No.: 1208986-85-9
• Molecular Formula: C₇₀H₁₁₇N₁₁O₁₄
• Molecular Weight: 1336.76
• Mol file: 1208986-85-9.mol

Synonyms:

Chemical Property of sarcosine-3-(4-methylbenzoate)-cyclosporin A

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sarcosine-3-(4-methylbenzoate)-cyclosporin A

There total 1 articles about sarcosine-3-(4-methylbenzoate)-cyclosporin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

4-bromomethylbenzoic Acid (6232-88-8) + cyclosporin A (59865-13-3) → sarcosine-3-(4-methylbenzoate)-cyclosporin A (1208986-85-9)

Guidance literature:

cyclosporin A; With chloro-trimethyl-silane; lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.666667h; Inert atmosphere;

4-bromomethylbenzoic Acid; In tetrahydrofuran; at 22 ℃; for 1h;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h;

DOI:10.1042/BJ20090332

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)-1,6-diaminohexane hydrobromide (352351-56-5) + sarcosine-3-(4-methylbenzoate)-cyclosporin A (1208986-85-9) → C91H141N13O15 (1262527-17-2)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1042/BJ20090332

upstream raw materials:

4-bromomethylbenzoic Acid

cyclosporin A

Downstream raw materials:

C₉₁H₁₄₁N₁₃O₁₅