9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

Base Information

Chemical Name:9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine
CAS No.:945594-48-9
Molecular Formula:C₃₃H₅₇N₇O₄Si₂
Molecular Weight:672.031
Hs Code.:

9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

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Chemical Property of 9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

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Technology Process of 9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

There total 5 articles about 9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945594-45-6
2-[4-(2-bromoethoxy)phenyl]-4,4,5,5-tetramethylimidazolidine-1,3-diol

: 945594-48-9
9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.71 g / imidazole / dimethylformamide / 29 h / 50 °C

2: 60.3 percent / K₂CO₃; KI / dimethylformamide / 25 h / 60 °C

3: methanol; CH₂Cl₂ / 0.58 h / 20 °C

With 1H-imidazole; potassium carbonate; potassium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b702606d

Reference yield:

: 945594-46-7
2-[4-(2-bromoethoxy)phenyl]-1,3-bis-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethylimidazolidine

: 945594-48-9
9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.71 g / imidazole / dimethylformamide / 29 h / 50 °C

2: 60.3 percent / K₂CO₃; KI / dimethylformamide / 25 h / 60 °C

3: methanol; CH₂Cl₂ / 0.58 h / 20 °C

4: 318.2 mg / Me₃SiI / dimethylformamide; acetonitrile / 23 h / 20 °C

5: 80.5 percent / tetrabutylammonium fluoride / dimethylformamide; tetrahydrofuran / 14 h / 20 °C

With 1H-imidazole; trimethylsilyl iodide; tetrabutyl ammonium fluoride; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b702606d

Reference yield:

: 14384-45-3
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine

: 945594-48-9
9-(2-{4-[1-(tert-butyldimethylsilanyloxy)-4,4,5,5-tetramethyl-3-(1-methyl-1-trimethylsilanylethoxy)-imidazolidin-2-yl]-phenoxy}-ethyl)-6-methoxy-9H-purin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 23 h / Heating

2: 1.71 g / imidazole / dimethylformamide / 29 h / 50 °C

3: 60.3 percent / K₂CO₃; KI / dimethylformamide / 25 h / 60 °C

4: methanol; CH₂Cl₂ / 0.58 h / 20 °C

With 1H-imidazole; potassium carbonate; potassium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1039/b702606d