Technology Process of Benzyl-O--(2->4)-O--(2->6)-3,4-di-O-benzyl-2-<(benzyloxycarbonyl)amino>-2-desoxy-α-D-glucopyranosid
There total 13 articles about Benzyl-O--(2->4)-O--(2->6)-3,4-di-O-benzyl-2-<(benzyloxycarbonyl)amino>-2-desoxy-α-D-glucopyranosid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) HgBr2, molecular sieve 4 Angstroem; 2.) NaOMe (1M) / 1.) toluene, CH2Cl2, 88 h, room temp.; 2.) CH3OH, 2.5 h
2: 78 percent / p-TosOH / dimethylformamide / 2.5 h / 0 °C
3: 44 percent / Hg(CN)2, HgBr2, molecular sieve 4 Angstroem / nitromethane / 108 h
4: 76 percent / TFA (90percent) / CH2Cl2 / 0.25 h
5: NaOMe / methanol / 1 h
With
4 A molecular sieve; sodium methylate; mercury(II) cyanide; toluene-4-sulfonic acid; trifluoroacetic acid; mercury dibromide;
In
methanol; nitromethane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) HgBr2, molecular sieve 4 Angstroem; 2.) NaOMe (1M) / 1.) toluene, CH2Cl2, 88 h, room temp.; 2.) CH3OH, 2.5 h
2: 78 percent / p-TosOH / dimethylformamide / 2.5 h / 0 °C
3: 44 percent / Hg(CN)2, HgBr2, molecular sieve 4 Angstroem / nitromethane / 108 h
4: 76 percent / TFA (90percent) / CH2Cl2 / 0.25 h
5: NaOMe / methanol / 1 h
With
4 A molecular sieve; sodium methylate; mercury(II) cyanide; toluene-4-sulfonic acid; trifluoroacetic acid; mercury dibromide;
In
methanol; nitromethane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) Ba(OH)2*8H2O, BaO / 1.) DMF, 1 h, room temp.; 2.) 22 h, room temp.
2: HBr (33percent in AcOH) / CHCl3 / 0.01 h
3: 1.) HgBr2, molecular sieve 4 Angstroem; 2.) NaOMe (1M) / 1.) toluene, CH2Cl2, 88 h, room temp.; 2.) CH3OH, 2.5 h
4: 78 percent / p-TosOH / dimethylformamide / 2.5 h / 0 °C
5: 44 percent / Hg(CN)2, HgBr2, molecular sieve 4 Angstroem / nitromethane / 108 h
6: 76 percent / TFA (90percent) / CH2Cl2 / 0.25 h
7: NaOMe / methanol / 1 h
With
barium dihydroxide; 4 A molecular sieve; hydrogen bromide; sodium methylate; mercury(II) cyanide; toluene-4-sulfonic acid; trifluoroacetic acid; mercury dibromide; barium(II) oxide;
In
methanol; nitromethane; dichloromethane; chloroform; N,N-dimethyl-formamide;
