N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide

Base Information

• Chemical Name: N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide
• CAS No.: 230961-33-8
• Molecular Formula: C₃₃H₄₂N₄O₄
• Molecular Weight: 558.721

Synonyms:

Chemical Property of N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide

There total 10 articles about N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)-6-[3-methyl-(4-phenyl)phenyl]hex-5-enoate → N1-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N4-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide (230961-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr

2: 2.5 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 0 °C

5: ammonium formate / ethanol; water / 1.25 h / Heating / reflux

With hydrogenchloride; hydrogen; ammonium formate; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water;

Reference yield:

tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)hex-5-enoate (230962-28-4) → N1-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N4-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide (230961-33-8)

Guidance literature:

Multi-step reaction with 6 steps

1: N-ethylmorpholine; / acetonitrile / 16.5 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr

3: 2.5 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 0 °C

6: ammonium formate / ethanol; water / 1.25 h / Heating / reflux

With N-ethylmorpholine;; hydrogenchloride; hydrogen; ammonium formate; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

3-methyl-4-phenylbromobenzene (5002-26-6) → N1-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N4-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide (230961-33-8)

Guidance literature:

Multi-step reaction with 6 steps

1: N-ethylmorpholine; / acetonitrile / 16.5 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr

3: 2.5 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 0 °C

6: ammonium formate / ethanol; water / 1.25 h / Heating / reflux

With N-ethylmorpholine;; hydrogenchloride; hydrogen; ammonium formate; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; acetonitrile;

upstream raw materials:

tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-[3-methyl-(4-phenyl)phenyl]hexanoate

tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)hex-5-enoate

3-methyl-4-phenylbromobenzene

2-methyl-4-bromoiodobenzene

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