3-Hydroxy-4-methoxypyridine-2-carboxylic acid

Base Information

• Chemical Name: 3-Hydroxy-4-methoxypyridine-2-carboxylic acid
• CAS No.: 210300-09-7
• Molecular Formula: C7H7NO4
• Molecular Weight: 169.137
• Hs Code.: 2933399990
• European Community (EC) Number: 815-418-6,953-797-0
• DSSTox Substance ID: DTXSID90452938
• Nikkaji Number: J959.721B
• Wikidata: Q72484933
• Mol file: 210300-09-7.mol

Synonyms:210300-09-7;3-Hydroxy-4-methoxypyridine-2-carboxylic acid;3-hydroxy-4-methoxypicolinic acid;2-Pyridinecarboxylic acid, 3-hydroxy-4-methoxy-;MFCD18254272;3-hydroxy-4-methoxy-pyridine-2-carboxylic Acid;SCHEMBL753212;3-hydroxy-4-methoxypicolinicacid;AMY9135;DTXSID90452938;OBHHCPRYWZKEIM-UHFFFAOYSA-N;3-hydroxy-4-methoxy picolinic acid;AKOS022711756;CS-13200;SY212542;CS-0102204;3-Hydroxy-4-methoxy-2-pyridinecarboxylic acid;EN300-332794;F20157

Chemical Property of 3-Hydroxy-4-methoxypyridine-2-carboxylic acid

Chemical Property:

• Boiling Point: 445.7±45.0 °C(Predicted)
• PKA: 1.27±0.50(Predicted)
• PSA: 79.65000
• Density: 1.437±0.06 g/cm3(Predicted)
• LogP: 0.49400
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 169.03750770
• Heavy Atom Count: 12
• Complexity: 173

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-4-methoxypicolinicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=NC=C1)C(=O)O)O

Technology Process of 3-Hydroxy-4-methoxypyridine-2-carboxylic acid

There total 19 articles about 3-Hydroxy-4-methoxypyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

carbon dioxide (124-38-9,18923-20-1) + 4-methoxy-3-methoxymethoxypyridine (210300-15-5) → 3-hydroxy-4-methoxy-pyridine-2-carboxylic acid (210300-09-7)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(98)00796-5

Reference yield: 97.0%

Lithium; 4-methoxy-3-methoxymethoxy-pyridine-2-carboxylate → 3-hydroxy-4-methoxy-pyridine-2-carboxylic acid (210300-09-7)

Guidance literature:

With hydrogenchloride; for 72h;

DOI:10.1016/S0040-4020(98)00777-7

Reference yield: 90.0%

6-BROMO-3-BENZYLOXY-4-METHOXYPYRIDINE-2-CARBOXYLIC ACID (321596-54-7) → 3-hydroxy-4-methoxy-pyridine-2-carboxylic acid (210300-09-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; triethylamine; In ethanol; for 3h; under 2327.23 - 2585.81 Torr;

DOI:10.1039/d0gc02063j

upstream raw materials:

carbon dioxide

4-methoxy-3-methoxymethoxypyridine

3-benzyloxy-4-methoxypicolinic acid

furfural

Downstream raw materials:

(3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate

3-hydroxy-4-methoxypyridine-2-carboxylic acid ethyl ester

3-hydroxy-4-methoxypyridine-2-carboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethylpyrazol-1-yl)acetyl]piperidin-4-yl}thiazol-4-yl)amide