Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate

Base Information

• Chemical Name: Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate
• CAS No.: 80353-98-6
• Molecular Formula: C₈H₇BrN₂O₂S
• Molecular Weight: 275.126
• Hs Code.: 2934100090
• European Community (EC) Number: 869-548-3
• Mol file: 80353-98-6.mol

Synonyms:80353-98-6;ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate;Ethyl 2-bromoimidazo[2,1-b]thiazole-6-carboxylate;SCHEMBL15545447;AMWIMQLEHJSRIR-UHFFFAOYSA-N;MFCD18426515;AKOS015835799;AF-0711;AT13438;CS-0151697;EN300-8672681;Ethyl2-bromoimidazo[2,1-b]thiazole-6-carboxylate;ethyl 2-bromoimidazo[2,1-b]thiazole-6-carboxilate;2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid ethyl ester

Chemical Property of Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate

Chemical Property:

• Melting Point: 208-210℃ (ethanol )
• PSA: 71.84000
• LogP: 2.33500
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 273.94116
• Heavy Atom Count: 14
• Complexity: 241

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN2C=C(SC2=N1)Br

Technology Process of Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate

There total 3 articles about Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

5-bromo-2-aminothiazole (3034-22-8) + ethyl Bromopyruvate (70-23-5) → ethyl 2-bromoimidazo<2,1-b>thiazole-6-carboxylate (80353-98-6)

Guidance literature:

In ethanol; for 5h; Heating;

Reference yield: 27.0%

ethyl Bromopyruvate (70-23-5) + 5-bromothiazol-2-amine hydrobromide (61296-22-8) → ethyl 2-bromoimidazo<2,1-b>thiazole-6-carboxylate (80353-98-6)

Guidance literature:

With triethylamine; In butanone; Reflux; Inert atmosphere;

Reference yield:

→ ethyl 2-bromoimidazo<2,1-b>thiazole-6-carboxylate (80353-98-6)

Guidance literature:

In toluene; Reflux; Dean-Stark;

upstream raw materials:

5-bromo-2-aminothiazole

ethyl Bromopyruvate

5-bromothiazol-2-amine hydrobromide