1-Acetyl-5,6-dimethoxyindoline

Base Information

Chemical Name:1-Acetyl-5,6-dimethoxyindoline
CAS No.:15937-10-7
Molecular Formula:C12H15NO3
Molecular Weight:221.256
Hs Code.:2933990090
DSSTox Substance ID:DTXSID20504818
Wikidata:Q82359569
Mol file:15937-10-7.mol

Synonyms:1-Acetyl-5,6-dimethoxyindoline;15937-10-7;1-(5,6-Dimethoxyindolin-1-yl)ethanone;1-(5,6-DIMETHOXY-2,3-DIHYDROINDOL-1-YL)ETHANONE;1-(5,6-Dimethoxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one;DTXSID20504818;FT-0706054

Suppliers and Price of 1-Acetyl-5,6-dimethoxyindoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 1-Acetyl-5,6-dimethoxyindoline

Chemical Property:

Boiling Point:452.528 °C at 760 mmHg
Flash Point:227.481 °C
PSA：38.77000
Density:1.172 g/cm³
LogP:1.67780
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:221.10519334
Heavy Atom Count:16
Complexity:269

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CCC2=CC(=C(C=C21)OC)OC

Technology Process of 1-Acetyl-5,6-dimethoxyindoline

There total 5 articles about 1-Acetyl-5,6-dimethoxyindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 74064-26-9
N-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]acetamide

: 15937-10-7
1-acetyl-2,3-dihydro-5,6-dimethoxy-1H-indole

Guidance literature:: With potassium tert-butylate; copper(II) oxalate; In 1-methyl-pyrrolidin-2-one; at 25 - 95 ℃; for 10h; Inert atmosphere;

Reference yield: 96.0%

: 66384-45-0
N-acetyl-2-iodo-4,5-dimethoxy-β-phenethylamine

: 15937-10-7
1-acetyl-2,3-dihydro-5,6-dimethoxy-1H-indole

Guidance literature:: With copper(II) oxalate; potassium carbonate; In N,N-dimethyl-formamide; at 25 - 85 ℃; for 9h; Inert atmosphere;

Reference yield:

: 6275-29-2
N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

: 15937-10-7
1-acetyl-2,3-dihydro-5,6-dimethoxy-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 96.3 percent / bromine / acetic acid / 2 h / Ambient temperature

2: 74 percent / sodium hydride, cuprous iodide / dimethylformamide / 1.) room temperature, 30 min, 2.) 80 - 85 deg C, 12 h

With copper(l) iodide; bromine; sodium hydride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/P19810000290