N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE

Base Information

• Chemical Name: N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE
• CAS No.: 6275-29-2
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• Hs Code.: 2924299090
• Mol file: 6275-29-2.mol

Synonyms:Acetamide, N-[2- (3, 4-dimethoxyphenyl)ethyl]-;N-Acetylhomoveratrylamine;N-Acetyl-3, 4-dimethoxyphenethylamine;N-(3, 4-Dimethoxyphenethyl)acetamide;Acetamide, N- (3,4-dimethoxyphenethyl)-;N-[2-(3,4-Dimethoxyphenyl)ethyl]acetamide;Acetamide, N-(2-(3,4-dimethoxyphenyl)ethyl)- (9CI);N-Acetyl-3,4-dimethoxyphenethylamine;

Chemical Property of N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 7.05E-07mmHg at 25°C
• Melting Point: 57.5-59 °C
• Refractive Index: 1.504
• Boiling Point: 408.4 °C at 760 mmHg
• PKA: 16.17±0.46(Predicted)
• Flash Point: 200.8 °C
• PSA: 47.56000
• Density: 1.067 g/cm³
• LogP: 1.77330

Purity/Quality:

99%, ^*data from raw suppliers

N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE

There total 15 articles about N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + acetyl chloride (75-36-5) → N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1039/b101712h

Reference yield: 99.0%

acetic anhydride (108-24-7) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2)

Guidance literature:

In dichloromethane; at 18 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c1ob05208j

Reference yield: 95.0%

N,N-dibenzoyl-N-2-(3,4-dimethoxyphenyl)ethylamine (174533-44-9) → N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; a) 0 deg C, 75 min, b) RT, overnight;

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

acetic acid

pyrrolidine

acetic anhydride

Downstream raw materials:

N-methyl-N-(3,4-dimethoxyphenethyl)acetamide

N-(2-acetyl-4,5-dimethoxyphenethyl)acetamide

N-<4,5-dimethoxy-2-(3-phenylpropenoyl)phenethyl>acetamide

N-(4,5-dimethoxy-2-(2-phenylacetyl)phenethyl)acetamide

Refernces

• 1、 Perego, Luca Alessandro,Blieck, Rémi,Groué, Antoine,Monnier, Florian,Taillefer, Marc,Ciofini, Ilaria,Grimaud, Laurence. "Copper-Catalyzed Hydroamination of Allenes: From Mechanistic Understanding to Methodology Development". . p. 4253 - 4264. Retrieved 2017.
• 2、 Kwan, Maria H. T.,Breen, Jessica,Bowden, Martin,Conway, Louis,Crossley, Ben,Jones, Martin F.,Munday, Rachel,Pokar, Nisha P. B.,Screen, Thomas,Blacker, A. John. "Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations". . p. 2458 - 2473. Retrieved 2021/02/06.
• 3、 Barrios-Rivera, Jonathan,Xu, Yingjian,Wills, Martin. "Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity". supporting information. p. 6283 - 6287. Retrieved 2020/09/02.