Methyl 5,6-dimethoxyindoline-1-carboxylate

Base Information

Chemical Name:Methyl 5,6-dimethoxyindoline-1-carboxylate
CAS No.:74054-32-3
Molecular Formula:C12H15NO4
Molecular Weight:237.255
Hs Code.:2933990090
DSSTox Substance ID:DTXSID80504819
Wikidata:Q82359570
Mol file:74054-32-3.mol

Synonyms:74054-32-3;Methyl 5,6-dimethoxyindoline-1-carboxylate;methyl 5,6-dimethoxy-2,3-dihydroindole-1-carboxylate;Methyl 5,6-dimethoxy-2,3-dihydro-1H-indole-1-carboxylate;2,3-Dihydro-5,6-dimethoxy-1-(methoxycarbonyl)-1H-indole;DTXSID80504819

Suppliers and Price of Methyl 5,6-dimethoxyindoline-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 6 raw suppliers

Chemical Property of Methyl 5,6-dimethoxyindoline-1-carboxylate

Chemical Property:

PSA：48.00000
LogP:1.89770
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:237.10010796
Heavy Atom Count:17
Complexity:284

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CCN2C(=O)OC)OC

Technology Process of Methyl 5,6-dimethoxyindoline-1-carboxylate

There total 2 articles about Methyl 5,6-dimethoxyindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.7%

: 74054-31-2
methyl 2-bromo-4,5-dimethoxyphenethylcarbamate

: 74054-32-3
2,3-dihydro-5,6-dimethoxy-1-methoxycarbonyl-1H-indole

Guidance literature:: With copper(l) iodide; sodium hydride; In N,N-dimethyl-formamide; 1.) room temperature, 30 min, 2.) 80 - 85 deg C, 12 h;
DOI:10.1039/P19810000290

Reference yield:

: 35690-71-2
[2-(3,4-dimethoxy-phenyl)-ethyl]-carbamic acid methyl ester

: 74054-32-3
2,3-dihydro-5,6-dimethoxy-1-methoxycarbonyl-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 95.6 percent / bromine / acetic acid / 2 h / Ambient temperature

2: 65.7 percent / sodium hydride, cuprous iodide / dimethylformamide / 1.) room temperature, 30 min, 2.) 80 - 85 deg C, 12 h

With copper(l) iodide; bromine; sodium hydride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/P19810000290

Reference yield:

: 74054-32-3
2,3-dihydro-5,6-dimethoxy-1-methoxycarbonyl-1H-indole

: 14430-23-0
5,6-dimethoxyindole

Guidance literature:: Multi-step reaction with 2 steps

1: 88.1 percent / manganese dioxide / CH₂Cl₂ / 72 h / Ambient temperature

2: 71.9 percent / Claisen's alkali / 0.5 h / Heating

With manganese(IV) oxide; Claisen's alkali; In dichloromethane;
DOI:10.1039/P19810000290