6-Bromoimidazo[1,2-a]pyridine-3-carboxylicacid

Base Information

• Chemical Name: 6-Bromoimidazo[1,2-a]pyridine-3-carboxylicacid
• CAS No.: 944896-42-8
• Molecular Formula: C8H5BrN2O2
• Molecular Weight: 241.044
• Hs Code.: 2933990090
• Mol file: 944896-42-8.mol

Synonyms:Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-bromo-;

Chemical Property of 6-Bromoimidazo[1,2-a]pyridine-3-carboxylicacid

Chemical Property:

• Refractive Index: 1.728
• PKA: -0.99±0.41(Predicted)
• PSA: 54.60000
• Density: 1.899 g/cm³
• LogP: 1.79500
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-bromoimidazo[1,2-a]pyridine-3-carboxylic acid?belongs to heterocyclic derivatives and can be used as pharmaceutical intermediates.

Technology Process of 6-Bromoimidazo[1,2-a]pyridine-3-carboxylicacid

There total 8 articles about 6-Bromoimidazo[1,2-a]pyridine-3-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

5-bromo-2-pyridylamine (1072-97-5) + ethyl 2-chloro-3-oxopropanoate (33142-21-1) → 6-bromoimidazo[1,2-a]pyridine-3-carboxylic acid (944896-42-8)

Guidance literature:

5-bromo-2-pyridylamine; ethyl 2-chloro-3-oxopropanoate; In ethanol; at 20 ℃; Inert atmosphere; Reflux; Large scale;

With water; sodium hydroxide; In ethanol; at 35 ℃; Reflux; Large scale;

Reference yield: 82.0%

ethyl 6-bromoimidazol[1,2-a]pyridine-3-carboxylate (372198-69-1) → 6-bromoimidazo[1,2-a]pyridine-3-carboxylic acid (944896-42-8)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 60 ℃;

DOI:10.1016/j.bmcl.2021.127881

Reference yield:

methyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate (1359656-01-1) → 6-bromoimidazo[1,2-a]pyridine-3-carboxylic acid (944896-42-8)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃;

upstream raw materials:

5-bromo-2-pyridylamine

ethyl 6-bromoimidazol[1,2-a]pyridine-3-carboxylate

ethyl 2-chloro-3-oxopropanoate

6-bromoimidazo[1,2-a]pyridine-3-carbonitrile

Downstream raw materials:

6-bromo-N-(3-methoxybenzyl)imidazo[1,2-a]pyridine-3-carboxamide

(6-(2-aminobenzo[d]oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl)(morpholino)methanone

6-bromoimidazo[1,2-a]pyridine-3-carbonitrile

6-bromoimidazo[1,2-a]pyridine-3-carboxamide

Refernces

• 1、 -. "Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof". . . Retrieved 2016/04/26.
• 2、 -. "2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE". Paragraph 1298; 1299. . Retrieved 2015/11/27.