4-PYRIDINECARBOXYLIC ACID, 2-(BROMOMETHYL)-, METHYL ESTER

Base Information

• Chemical Name: 4-PYRIDINECARBOXYLIC ACID, 2-(BROMOMETHYL)-, METHYL ESTER
• CAS No.: 914639-05-7
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.061
• Hs Code.: 2933399090
• Mol file: 914639-05-7.mol

Synonyms:Methyl2-(bromomethyl)isonicotinate;

Chemical Property of 4-PYRIDINECARBOXYLIC ACID, 2-(BROMOMETHYL)-, METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 294.455°C at 760 mmHg
• Flash Point: 131.882°C
• PSA: 39.19000
• Density: 1.533g/cm³
• LogP: 1.76310
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

METHYL 2-(BROMOMETHYL)ISONICOTINATE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PYRIDINECARBOXYLIC ACID, 2-(BROMOMETHYL)-, METHYL ESTER

There total 5 articles about 4-PYRIDINECARBOXYLIC ACID, 2-(BROMOMETHYL)-, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 2-(hydroxymethyl)pyridine-4-carboxylate (58481-17-7) → methyl 2-(bromomethyl)isonicotinate (914639-05-7)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 5h; Cooling with ice;

Reference yield: 66.0%

methyl 2-methylisonicotinate (16830-24-3) → methyl 2-(bromomethyl)isonicotinate (914639-05-7)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 5h; Reflux;

Reference yield:

2-methylisonicotinic acid (4021-11-8) → methyl 2-(bromomethyl)isonicotinate (914639-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 48 h / Reflux

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In tetrachloromethane;

upstream raw materials:

4-pyridinecarboxylic acid, methyl ester

methyl 2-(hydroxymethyl)pyridine-4-carboxylate

methyl 2-methylisonicotinate

2-methylisonicotinic acid

Refernces

• 1、 -. "Five-membered or six-membered heterocyclic pyrimidine compound and applications thereof". Paragraph 0508; 0510-0511; 0516-0519. . Retrieved 2020/05/08.
• 2、 -. "ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN INHIBITORS AND THEIR USE IN THE TREATMENT OF FIBRINOLYSIS RELATED DISEASES". . . Retrieved 2012/04/23.