diethyl N²,N⁶-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate

Base Information

• Chemical Name: diethyl N²,N⁶-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate
• CAS No.: 121395-04-8
• Molecular Formula: C₃₀H₃₉N₃O₉
• Molecular Weight: 585.654
• Mol file: 121395-04-8.mol

Synonyms:

Chemical Property of diethyl N²,N⁶-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl N²,N⁶-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate

There total 3 articles about diethyl N²,N⁶-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H39N3O9S → diethyl N2,N6-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate (121395-04-8)

Guidance literature:

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; at -10 ℃; for 0.25h;

DOI:10.1039/c8ob00676h

Reference yield:

L-aspartic acid diethyl ester (13552-87-9) + Nα.Nε-bis-benzyloxycarbonyl-L-lysyl azide (911480-68-7) → diethyl N2,N6-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate (121395-04-8)

Guidance literature:

With diethyl ether;

Reference yield:

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine (405-39-0) + diethyl L-aspartate hydrochloride (16115-68-7) → diethyl N2,N6-bis((benzyloxy)carbonyl)-L-lysyl-L-aspartate (121395-04-8)

Guidance literature:

Multistep reaction; (i) PCl₃, Py, (ii) /BRN= 4824216/;

upstream raw materials:

L-aspartic acid diethyl ester

N^α.N^ε-bis-benzyloxycarbonyl-L-lysyl azide

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

diethyl L-aspartate hydrochloride

Downstream raw materials:

(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-succinic acid

Lys-Asp