3-(R)-PIPERIDINYL PHTHALIMIDE HYDROCHLORIDE

Base Information

• Chemical Name: 3-(R)-PIPERIDINYL PHTHALIMIDE HYDROCHLORIDE
• CAS No.: 886588-61-0
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Hs Code.: 2933399090
• Mol file: 886588-61-0.mol

Synonyms:3-(R)-PIPERIDINYL PHTHALIMIDE HYDROCHLORIDE;(R)-2-(Piperidin-3-yl)isoindoline-1,3-dione hydrochloride;2-(3R)-3-Piperidinyl-1H-isoindole-1,3(2H)-dione

Chemical Property of 3-(R)-PIPERIDINYL PHTHALIMIDE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 377.411 °C at 760 mmHg
• PKA: 9.37±0.10(Predicted)
• Flash Point: 182.052 °C
• PSA: 49.41000
• Density: 1.288 g/cm³
• LogP: 2.10330

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(Piperidin-3-Yl)isoindoline-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(R)-PIPERIDINYL PHTHALIMIDE HYDROCHLORIDE

There total 1 articles about 3-(R)-PIPERIDINYL PHTHALIMIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

3-(R)-aminopiperidine dihydrochloride (334618-23-4) + phthalic anhydride (85-44-9) → C13H14N2O2 (886588-61-0,886588-71-2)

Guidance literature:

With acetic acid; triethylamine; In toluene; at 20 - 125 ℃; Reflux;

Reference yield: 91.0%

8-bromo-7-(but2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6–dione (666816-98-4) + C13H14N2O2 (886588-61-0,886588-71-2) + 2-chloromethyl-4-methylquinazoline (109113-72-6) → (R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine2,6-dione (886588-63-2)

Guidance literature:

8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione; C₁₃H₁₄N₂O₂; With 1-methyl-pyrrolidin-2-one; potassium carbonate; potassium iodide; at 50 - 60 ℃;

2-chloromethyl-4-methylquinazoline;

Reference yield:

C13H14N2O2 (886588-61-0,886588-71-2) → Linagliptin (668270-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 75 °C

2: hydrogenchloride / water / 65 °C

3: acetic acid / water / 75 °C

With hydrogenchloride; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide;

upstream raw materials:

3-(R)-aminopiperidine dihydrochloride

phthalic anhydride

Downstream raw materials:

C₂₃H₂₇N₃O₄S

C₁₇H₂₈N₂O₄S

C₂₀H₂₄Cl₂N₂O₄S

C₂₀H₂₅FN₂O₄S

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