Technology Process of N-[2-butyl-3-[4-(3-(di-n-butylamino)propoxy)benzoyl]-5-benzofuranyl]methanesulfonamide hydrobromide
There total 9 articles about N-[2-butyl-3-[4-(3-(di-n-butylamino)propoxy)benzoyl]-5-benzofuranyl]methanesulfonamide hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium formate / palladium 10% on activated carbon / methanol
2: water / 2 h
3: ammonia / dichloromethane
4: hydrogen bromide / ethyl acetate
With
ammonia; hydrogen bromide; ammonium formate;
palladium 10% on activated carbon;
In
methanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / chlorobenzene / 2 h / 25 °C / Reflux
2.1: aluminum (III) chloride / chlorobenzene / 2 h / 75 °C
2.2: 0.5 h / 5 - 65 °C
3.1: potassium carbonate / butanone / 20 h / 85 °C
3.3: 0.5 h / 25 - 65 °C
4.1: potassium carbonate / toluene; water
5.1: hydrogen / Raney Nickel / methanol / 8 h / 55 °C / 3677.86 Torr
5.2: 0.5 h / 25 - 65 °C
6.1: potassium carbonate / toluene; water / 1 h / 35 °C
7.1: toluene / 3.5 h / 108 °C
7.2: 0.5 h / 60 °C
8.1: hydrogen bromide / ethyl acetate; hexane / 1 h / 25 - 65 °C
With
aluminum (III) chloride; hydrogen bromide; hydrogen; potassium carbonate;
aluminum (III) chloride;
In
methanol; hexane; water; ethyl acetate; chlorobenzene; toluene; butanone;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / chlorobenzene / 2 h / 75 °C
1.2: 0.5 h / 5 - 65 °C
2.1: potassium carbonate / butanone / 20 h / 85 °C
2.3: 0.5 h / 25 - 65 °C
3.1: potassium carbonate / toluene; water
4.1: hydrogen / Raney Nickel / methanol / 8 h / 55 °C / 3677.86 Torr
4.2: 0.5 h / 25 - 65 °C
5.1: potassium carbonate / toluene; water / 1 h / 35 °C
6.1: toluene / 3.5 h / 108 °C
6.2: 0.5 h / 60 °C
7.1: hydrogen bromide / ethyl acetate; hexane / 1 h / 25 - 65 °C
With
aluminum (III) chloride; hydrogen bromide; hydrogen; potassium carbonate;
Raney Nickel;
In
methanol; hexane; water; ethyl acetate; chlorobenzene; toluene; butanone;
