2-Amino-5-bromonicotinaldehyde

Base Information

• Chemical Name: 2-Amino-5-bromonicotinaldehyde
• CAS No.: 206997-15-1
• Molecular Formula: C6H5BrN2O
• Molecular Weight: 201.023
• Hs Code.: 2933399090
• Mol file: 206997-15-1.mol

Synonyms:2-AMINO-5-BROMOPYRIDINE-3-CARBOXALDEHYDE;

Chemical Property of 2-Amino-5-bromonicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.00112mmHg at 25°C
• Melting Point: 167-169
• Boiling Point: 300.5°C at 760 mmHg
• PKA: 2.74±0.49(Predicted)
• Flash Point: 135.5°C
• PSA: 55.98000
• Density: 1.782g/cm³
• LogP: 1.82000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-bromonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-bromonicotinaldehyde

There total 2 articles about 2-Amino-5-bromonicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-Aminonicotinaldehyde (7521-41-7) → 2-amino-5-bromo-3-pyridinecarbaldehyde (206997-15-1)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 2h; Reflux;

Reference yield:

2-amino-5-bromo-3-(hydroxymethyl)pyridine (335031-01-1) → 2-amino-5-bromo-3-pyridinecarbaldehyde (206997-15-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Inert atmosphere;

DOI:10.1039/c6ob01452f

Reference yield: 90.0%

2-amino-5-bromo-3-pyridinecarbaldehyde (206997-15-1) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → C21H13BrN2O

Guidance literature:

With sodium hydrogensulfate on silicagel; In neat (no solvent); at 80 ℃; for 0.416667h; Green chemistry;

upstream raw materials:

2-Aminonicotinaldehyde

2-amino-5-bromo-3-(hydroxymethyl)pyridine

Downstream raw materials:

6-bromo-2-(4-fluorophenyl)-1,8-naphthyridine

ethyl 6-bromo-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

6-bromo-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide

2-(4-bromophenyl)-6-bromo-1,8-naphthyridine

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