2-Amino-5-bromo-3-(hydroxymethyl)pyridine

Base Information

• Chemical Name: 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
• CAS No.: 335031-01-1
• Molecular Formula: C6H7BrN2O
• Molecular Weight: 203.038
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00447395
• Wikidata: Q72438938
• Mol file: 335031-01-1.mol

Synonyms:2-amino-5-bromo-3-(hydroxymethyl)pyridine;335031-01-1;(2-amino-5-bromopyridin-3-yl)methanol;2-Amino-5-bromo-3-pyridinemethanol;2-Amino-5-bromopyridine-3-methanol;(2-Amino-5-bromo-pyridin-3-yl)-methanol;(2-Amino-5-bromo-3-pyridinyl)methanol;3-Pyridinemethanol, 2-amino-5-bromo-;MFCD05664025;SCHEMBL514211;DTXSID00447395;HIVQAWXDBPYNDU-UHFFFAOYSA-N;CL0039;AKOS005071538;AA-0702;AB22233;AC-3563;CS-W003239;2-amino-3-hyroxymethyl-5-bromopyridine;SY007504;2-Amino-5-Bromo-3-Hydroxymethyl Pyridine;A5969;AM20070220;FT-0602738;EN300-213226;J-500627;Z1741973231

Chemical Property of 2-Amino-5-bromo-3-(hydroxymethyl)pyridine

Chemical Property:

• Vapor Pressure: 2.67E-05mmHg at 25°C
• Melting Point: 137-140 °C
• Refractive Index: 1.665
• Boiling Point: 343.5 °C at 760mmHg
• PKA: 13.16±0.10(Predicted)
• Flash Point: 161.6 °C
• PSA: 59.14000
• Density: 1.766 g/cm³
• LogP: 1.49980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Acetone, Ethyl Acetate, Methanol
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 201.97418
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-bromo-3-pyridinemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1CO)N)Br
• Uses: 2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 2-Amino-5-bromo-3-(hydroxymethyl)pyridine

There total 4 articles about 2-Amino-5-bromo-3-(hydroxymethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(2-amino-3-pyridinyl)methanol (23612-57-9) → 2-amino-5-bromo-3-(hydroxymethyl)pyridine (335031-01-1)

Guidance literature:

With bromine; In acetic acid; at 20 ℃; Product distribution / selectivity;

Reference yield: 75.0%

(2-amino-3-pyridinyl)methanol (23612-57-9) → Petroleum ether + 2-amino-5-bromo-3-(hydroxymethyl)pyridine (335031-01-1)

Guidance literature:

With bromine; In sodium carbonate; acetic acid;

Reference yield:

2-amino-5-bromonicotinicacid (52833-94-0) → 2-amino-5-bromo-3-(hydroxymethyl)pyridine (335031-01-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1039/c6ob01452f

upstream raw materials:

(2-amino-3-pyridinyl)methanol

2-aminopyridin-3-carboxylic acid

2-amino-5-bromonicotinicacid

Downstream raw materials:

2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

6-bromo-2-oxo-1,4-dihydro-2 H-pyrido[2,3-d ]-1,3-oxazine

1-(4-(6-amino-5-(hydroxymethyl)pyridin-3-yl)phenyl)-3-(5-tert-butylisoxazol-3-yl)urea

(2-amino-5-(4-aminophenyl)pyridin-3-yl)methanol