1,3-Dichloro-2-(trifluoromethoxy)benzene

Base Information

Chemical Name:1,3-Dichloro-2-(trifluoromethoxy)benzene
CAS No.:97608-49-6
Molecular Formula:C7H3Cl2F3O
Molecular Weight:231.00
Hs Code.:2909309090
DSSTox Substance ID:DTXSID30539732
Wikidata:Q82415533
Mol file:97608-49-6.mol

Synonyms:1,3-Dichloro-2-(trifluoromethoxy)benzene;97608-49-6;2,6-DICHLORO(TRIFLUOROMETHOXY)BENZENE;Benzene, 1,3-dichloro-2-(trifluoromethoxy)-;SCHEMBL8978656;AMY8680;DTXSID30539732;MFCD14697984;AKOS015850057;2,6-Dichlorophenyl trifluoromethyl ether;2,6-Dichloro-1-(trifluoromethoxy)benzene;F95146

Suppliers and Price of 1,3-Dichloro-2-(trifluoromethoxy)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,3-Dichloro-2-(trifluoromethoxy)benzene
5g
$ 435.00

Matrix Scientific
2,6-Dichloro(trifluoromethoxy)benzene 98%
25g
$ 1453.00

Matrix Scientific
2,6-Dichloro(trifluoromethoxy)benzene 98%
5g
$ 415.00

Matrix Scientific
2,6-Dichloro(trifluoromethoxy)benzene 98%
1g
$ 103.00

Crysdot
1,3-Dichloro-2-(trifluoromethoxy)benzene 98%
1g
$ 180.00

Crysdot
1,3-Dichloro-2-(trifluoromethoxy)benzene 98%
5g
$ 630.00

American Custom Chemicals Corporation
2,6-DICHLORO(TRIFLUOROMETHOXY)BENZENE 95.00%
1G
$ 690.69

American Custom Chemicals Corporation
2,6-DICHLORO(TRIFLUOROMETHOXY)BENZENE 95.00%
5G
$ 1206.98

Alichem
2,6-Dichloro(trifluoromethoxy)benzene
1g
$ 1475.10

Alichem
2,6-Dichloro(trifluoromethoxy)benzene
500mg
$ 815.00

Total 40 raw suppliers

Chemical Property of 1,3-Dichloro-2-(trifluoromethoxy)benzene

Chemical Property:

PSA：9.23000
LogP:3.89200
Storage Temp.:2-8°C
XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:229.9513046
Heavy Atom Count:13
Complexity:164

Purity/Quality:

98% ^*data from raw suppliers

1,3-Dichloro-2-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)Cl)OC(F)(F)F)Cl
Uses 1,3-Dichloro-2-(trifluoromethoxy)benzene is a useful synthetic intermediate in the synthesis of 4-Chloro-3-(trifluoromethoxy)aniline (C421915); a reagent in the preparation of diazepanone compounds as chemokine receptor antagonists for the treatment of inflammatory diseases.

Technology Process of 1,3-Dichloro-2-(trifluoromethoxy)benzene

There total 4 articles about 1,3-Dichloro-2-(trifluoromethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3,5-bis(trifluoromethyl)phenyl)-4-nitro-1-(trifluoromethoxy)-6-(trifluoromethyl)-1H-benzo[d]imidazole

: 541-73-1
1,3-Dichlorobenzene

: 451-85-4
2,4-dichloro-1-(trifluoromethoxy)benzene

: 97608-49-6
1,3-dichloro-2-(trifluoromethoxy)benzene

Guidance literature:: With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In acetonitrile; at 23 ℃; for 16h; Overall yield = 61 %Spectr.; regioselective reaction; Sealed tube; Irradiation;
DOI:10.1002/anie.201800598

Reference yield:

: 97608-48-5
1,3-Dichloro-2-trichloromethoxy-benzene

: 97608-49-6
1,3-dichloro-2-(trifluoromethoxy)benzene

Guidance literature:: With hydrogen fluoride; at 140 - 160 ℃; for 6h; under 30002.4 Torr; Yield given;

Reference yield:

: 87-65-0
2,6-Dichlorophenol

: 97608-49-6
1,3-dichloro-2-(trifluoromethoxy)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / NaOH / H₂O / 0.5 h / 90 °C

2: 24.5 percent / Cl₂ / PCl₅ / 11.5 h / 195 °C

3: HF / 6 h / 140 - 160 °C / 30002.4 Torr

With sodium hydroxide; hydrogen fluoride; chlorine; phosphorus pentachloride; In water;