2-Boc-8-oxo-2-azaspiro[4.5]decane

Base Information

• Chemical Name: 2-Boc-8-oxo-2-azaspiro[4.5]decane
• CAS No.: 1272758-17-4
• Molecular Formula: C₁₄H₂₃NO₃
• Molecular Weight: 253.342
• Mol file: 1272758-17-4.mol

Synonyms:

Chemical Property of 2-Boc-8-oxo-2-azaspiro[4.5]decane

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl8-oxo-2-azaspiro[4.5]decane-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Boc-8-oxo-2-azaspiro[4.5]decane

There total 11 articles about 2-Boc-8-oxo-2-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.16%

tert-butyl 1,4-dioxo-10-azabisspiro[4.2.48.25]tetradecane-10-carboxylate → tert-butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate (1272758-17-4)

Guidance literature:

With pyridinium p-toluenesulfonate; In tetrahydrofuran; water; at 70 ℃; for 15h;

Reference yield: 54.5%

di-tert-butyl dicarbonate (24424-99-5) + 2-azaspiro[4.5]decane-8-one → tert-butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate (1272758-17-4)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate (51656-91-8) → tert-butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate (1272758-17-4)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / Reflux

2: hydrogen / water; ethanol / 72 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux

4: hydrogenchloride / water; methanol / 20 °C

5: sodium carbonate / water; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; In tetrahydrofuran; methanol; ethanol; water;

upstream raw materials:

di-tert-butyl dicarbonate

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

cyclohexanedione monoethylene ketal

ethyl 2-(8-(nitromethyl)-1,4-dioxaspiro-[4,5]-decan-8-yl-acetate)