(R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid

Base Information

Chemical Name:(R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid
CAS No.:208755-96-8
Molecular Formula:C₁₁H₁₁F₂N₃O₃
Molecular Weight:271.223
Hs Code.:

Synonyms:

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Chemical Property of (R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid

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Technology Process of (R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid

There total 9 articles about (R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 208755-96-8
(R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid

Guidance literature:: Multi-step reaction with 9 steps

1: 62 percent / NaH

2: 1.) (COCl)2, 2.) DMSO, Et₃N

3: 67 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / -78 °C

4: 56 percent / Dowex 50-H₊ / methanol

5: 95 percent / imidazole

6: pyridine

7: NaN₃ / dimethylformamide

8: t-Bu₄NF / tetrahydrofuran

9: CrO₃, H₂SO₄

With pyridine; 1H-imidazole; chromium(VI) oxide; sodium azide; oxalyl dichloride; diethylamino-sulfur trifluoride; Dowex 50-H₊; sulfuric acid; sodium hydride; dimethyl sulfoxide; tetra(tert-butyl)-ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00168-1

Reference yield:

: 117399-58-3
(1S)-2-(benzyloxy)-1-[(4S)-2,2-dimethyl-1,3-dioxolane-4-yl]-ethan-1-ol

: 208755-96-8
(R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) (COCl)2, 2.) DMSO, Et₃N

2: 67 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / -78 °C

3: 56 percent / Dowex 50-H₊ / methanol

4: 95 percent / imidazole

5: pyridine

6: NaN₃ / dimethylformamide

7: t-Bu₄NF / tetrahydrofuran

8: CrO₃, H₂SO₄

With pyridine; 1H-imidazole; chromium(VI) oxide; sodium azide; oxalyl dichloride; diethylamino-sulfur trifluoride; Dowex 50-H₊; sulfuric acid; dimethyl sulfoxide; tetra(tert-butyl)-ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00168-1

Reference yield:

: 208755-92-4
(2S)-4-(benzyloxy)-3,3-difluorobutane-1,2-diol

: 208755-96-8
(R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / imidazole

2: pyridine

3: NaN₃ / dimethylformamide

4: t-Bu₄NF / tetrahydrofuran

5: CrO₃, H₂SO₄

With pyridine; 1H-imidazole; chromium(VI) oxide; sodium azide; sulfuric acid; tetra(tert-butyl)-ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00168-1