(2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione

Base Information

• Chemical Name: (2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione
• CAS No.: 259540-44-8
• Molecular Formula: C₄₄H₅₀N₄O₈
• Molecular Weight: 762.903
• Mol file: 259540-44-8.mol

Synonyms:

Chemical Property of (2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione

There total 1 articles about (2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,5S)-1-(3-(3,4-dimethoxyphenyl)propanoyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone → (2R,3S)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione (259540-45-9) + (2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione (259540-44-8)

Guidance literature:

With titanium tetrachloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 24h; Further Variations:; Reagents; reaction time; Product distribution;

DOI:10.1021/jo991317o

Reference yield:

(2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione (259540-44-8) → (2R,3R)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-diol (58311-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: LiOH*H₂O; H₂O / Heating

2: LiAlH₄ / tetrahydrofuran / 12 h / Heating

With lithium hydroxide; lithium aluminium tetrahydride; water; In tetrahydrofuran; 1: Hydrolysis / 2: Reduction;

DOI:10.1021/jo991317o

Reference yield:

(2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione (259540-44-8) → (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid (15813-34-0)

Guidance literature:

With lithium hydroxide; water; Heating;

DOI:10.1021/jo991317o

Downstream raw materials:

(1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid

(2R,3R)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-diol