(1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid

Base Information

• Chemical Name: (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid
• CAS No.: 15813-34-0
• Molecular Formula: C₂₂H₂₆O₈
• Molecular Weight: 418.444
• Mol file: 15813-34-0.mol

Synonyms:(1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid

Chemical Property of (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid

There total 11 articles about (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,3-bis(3,4-dimethoxybenzylidene)butanedioic acid (73119-35-4) → D,L-2,3-bis(3,4-dimethoxybenzyl)succinic acid (15813-34-0,15905-29-0,93609-04-2,126965-32-0) + meso-2,3-bis(3,4-dimethoxybenzyl)succinic acid

Guidance literature:

With sodium hydroxide; hydrogen; Ra-Ni;

DOI:10.1021/jm010359d

Reference yield:

(2R,3R)-1,4-bis[(4S)-4-isopropyl-2-oxo(1,3-oxazolidin-3-yl)]-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione (259540-37-9) → (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid (15813-34-0)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; at 20 ℃;

DOI:10.1021/jo991317o

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → D,L-2,3-bis(3,4-dimethoxybenzyl)succinic acid (15813-34-0,15905-29-0,93609-04-2,126965-32-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating

2: 79 percent / H₂SO₄ / toluene / 16 h / Heating

3: 48 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating

4: 82 percent / 1.) 2M aq. NaOH, 2.) aq. HCl / 12 h / Heating

5: H₂

With hydrogenchloride; sodium hydroxide; sulfuric acid; potassium tert-butylate; hydrogen; In toluene; tert-butyl alcohol;

DOI:10.1016/0040-4020(96)00761-2

upstream raw materials:

D,L-2,3-bis(3,4-dimethoxybenzyl)succinic acid

(2R,3R)-1,4-bis[(4S)-4-isopropyl-2-oxo(1,3-oxazolidin-3-yl)]-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione

(2R,3R)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione

2,3-bis(3,4-dimethoxybenzylidene)butanedioic acid

Downstream raw materials:

D_g-threo-2.3-bis-(3.4-dimethoxy-benzyl)-succinic acid

phyllanthin

(2R,3R)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-diol

D_g-threo-2,3-bis-(3,4-dimethoxy-benzyl)-butanediol-(1,4)