3,3-Diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one

Base Information

Chemical Name:3,3-Diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one
CAS No.:204855-17-4
Molecular Formula:C₁₉H₂₇N₃O₃
Molecular Weight:345.442
Hs Code.:
DSSTox Substance ID:DTXSID50432392

Synonyms:204855-17-4;3,3-diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one;3,3-diethyl-4-[4-(4-methylpiperazine-1-carbonyl)phenoxy]azetidin-2-one;SCHEMBL6430758;DTXSID50432392;KWUMOFXREQVFQW-UHFFFAOYSA-N;4-[4-[[(4-methyl)piperazin-1-yl]carbonyl]phenoxy]-3,3-diethyl-2-azetidinone

Suppliers and Price of 3,3-Diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 3,3-Diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:345.20524173
Heavy Atom Count:25
Complexity:490

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C(NC1=O)OC2=CC=C(C=C2)C(=O)N3CCN(CC3)C)CC

Technology Process of 3,3-Diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one

There total 4 articles about 3,3-Diethyl-4-(4-(4-methylpiperazine-1-carbonyl)phenoxy)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₁₉H₂₇N₃O₃*C₁₂H₁₈O₇

: 204855-17-4
3,3-diethyl-4-{4-[(4-methylpiperazin-1-yl)carbonyl]phenoxy}azetidin-2-one

Guidance literature:: C₁₉H₂₇N₃O₃*C₁₂H₁₈O₇; With potassium carbonate; sodium chloride; In Isopropyl acetate; water; for 0.25h; Large scale;

With tetrabutylammomium bromide; 1-(4-hydroxybenzoyl)-4-methyl-piperazine; In Isopropyl acetate; water; at 60 ℃; Large scale;
DOI:10.1021/op015507o

Reference yield:

: 142935-44-2
4-Propionyloxy-3,3-diethylazetidin-2-one

: 85858-94-2
1-(4-hydroxybenzoyl)-4-methyl-piperazine

: 204855-17-4
3,3-diethyl-4-{4-[(4-methylpiperazin-1-yl)carbonyl]phenoxy}azetidin-2-one

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In Isopropyl acetate; water; at 45 ℃; for 2.2h; Large scale;
DOI:10.1021/op015507o

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 204855-17-4
3,3-diethyl-4-{4-[(4-methylpiperazin-1-yl)carbonyl]phenoxy}azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / ethyl acetate / 50 °C / Reflux

2: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / Isopropyl acetate; water / 2.2 h / 45 °C / Large scale

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; dicyclohexyl-carbodiimide; In Isopropyl acetate; water; ethyl acetate;
DOI:10.1021/op015507o