Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromide

Base Information

• Chemical Name: Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromide
• CAS No.: 923571-17-9
• Molecular Formula: C24H22BrNO4
• Molecular Weight: 468.347
• Mol file: 923571-17-9.mol

Synonyms:1-benzyl-4-(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonyl)pyridin-1-ium bromide;PyridiniuM, 4-[(2,3-dihydro-5,6-diMethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylMethyl)-, broMide

Chemical Property of Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromide

Chemical Property:

• PSA: 56.48000
• LogP: 0.28150

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromide

There total 1 articles about Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)carbonyl]-1-(phenylmethyl)-, bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5,6-dimethoxy-2-(pyridine-4-carbonyl)indan-1-one (923571-15-7) + benzyl bromide (100-39-0) → 1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium bromide (923571-17-9)

Guidance literature:

In toluene; cyclohexanol; at 114 ℃; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium bromide (923571-17-9) → 2-[(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)hydroxymethyl]-5,6-dimethoxyindan-1-one (923571-19-1)

Guidance literature:

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium bromide; With potassium hydroxide; sodium tetrahydroborate; In methanol; water; at 10 - 18 ℃; for 0.666667h;

With hydrogenchloride; water; In methanol; at 20 ℃; pH=~ 4;

With potassium hydroxide; In dichloromethane; water; at 20 ℃; pH=~ 8;

Reference yield:

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium bromide (923571-17-9) → donepezil hydrochloride (142057-77-0)

Guidance literature:

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium bromide; With sulfuric acid; hydrogen; platinum on activated charcoal; In methanol; at 35 ℃; under 7500.75 Torr;

With sodium hydroxide; In dichloromethane; water; pH=6 - 7;

With hydrogenchloride; In methanol; at 0 - 5 ℃; Product distribution / selectivity;

upstream raw materials:

5,6-dimethoxy-2-(pyridine-4-carbonyl)indan-1-one

benzyl bromide

Downstream raw materials:

2-[(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)hydroxymethyl]-5,6-dimethoxyindan-1-one

donepezil hydrochloride

C₂₄H₂₇NO₄

C₂₄H₂₇NO₄

Refernces