1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl-

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl-
CAS No.:1187448-81-2
Molecular Formula:C12H15ClN2
Molecular Weight:222.718
Hs Code.:
Mol file:1187448-81-2.mol

Synonyms:1H-Pyrazolo[3,4-d]pyrimidine,4-chloro-1-(3-pyridinyl);4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-boronic acid;4-chloro-2-(1,1-dimethylethyl)-1H-pyrrolo[2,3-b]pyridine;4-CHLORO-1-(PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE;4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid;4-chloro-2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine;

Suppliers and Price of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl-

Chemical Property:

PSA：28.68000
LogP:3.82220

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl-

There total 4 articles about 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187448-78-7
2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

: 1187448-81-2
4-chloro-2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide; With methanesulfonyl chloride; In N,N-dimethyl-formamide; at 50 ℃; for 1.25h;

With sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

: 591-22-0
3,5-Lutidine

: 1187448-81-2
4-chloro-2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene / 0 °C / Inert atmosphere

1.2: 0 - 5 °C / Inert atmosphere

1.3: 4 h / 60 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; ethyl acetate / 0 °C / Cooling with ice-NaCl

3.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 1.25 h / 50 °C

With methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; ethylbenzene; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 630-18-2
tert-butyl isocyanide

: 1187448-81-2
4-chloro-2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene / 0 °C / Inert atmosphere

1.2: 0 - 5 °C / Inert atmosphere

1.3: 4 h / 60 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; ethyl acetate / 0 °C / Cooling with ice-NaCl

3.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 1.25 h / 50 °C

With methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; ethylbenzene; ethyl acetate; N,N-dimethyl-formamide;