C₃₂H₂₃N₃OS₃

Base Information

• Chemical Name: C₃₂H₂₃N₃OS₃
• CAS No.: 1443778-29-7
• Molecular Formula: C₃₂H₂₃N₃OS₃
• Molecular Weight: 561.752
• Mol file: 1443778-29-7.mol

Synonyms:

Chemical Property of C₃₂H₂₃N₃OS₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₃N₃OS₃

There total 10 articles about C₃₂H₂₃N₃OS₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C29H21N3OS3 (1616428-65-9) + propargyl bromide (106-96-7) → C32H23N3OS3 (1443778-29-7)

Guidance literature:

With caesium carbonate; In acetone; toluene; Reflux;

DOI:10.1039/c4cc02179g

Reference yield:

2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2) → C32H23N3OS3 (1443778-29-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 20 °C

3.1: n-butyllithium / diethyl ether / 1.5 h / -78 °C

3.2: 20 °C

4.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

5.1: boron tribromide / dichloromethane / -78 - 20 °C

6.1: caesium carbonate / toluene; acetone / Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; boron tribromide; caesium carbonate; cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1039/c4cc02179g

Reference yield:

5-methyl-2-phenyl-4-(2-phenylthiazol-4-yl)thiazole (1616428-67-1) → C32H23N3OS3 (1443778-29-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 70 °C

2: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

3: boron tribromide / dichloromethane / -78 - 20 °C

4: caesium carbonate / toluene; acetone / Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; caesium carbonate; cesium fluoride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1039/c4cc02179g

upstream raw materials:

1,4-dibromopentane-2,3-dione

5-methyl-2-phenyl-4-(2-phenylthiazol-4-yl)thiazole

5-bromo-5’-methyl-4,4’-bi-(2-phenyl)-thiazole

2,3-Pentanedione

Downstream raw materials:

C₄₁H₄₄N₆O₄S₃Si