C₂₈H₂₇FN₄O₂S

Base Information

Chemical Name:C₂₈H₂₇FN₄O₂S
CAS No.:1617505-28-8
Molecular Formula:C₂₈H₂₇FN₄O₂S
Molecular Weight:502.612
Hs Code.:

C<sub>28</sub>H<sub>27</sub>FN<sub>4</sub>O<sub>2</sub>S

Synonyms:

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Chemical Property of C₂₈H₂₇FN₄O₂S

Chemical Property:

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Technology Process of C₂₈H₂₇FN₄O₂S

There total 4 articles about C₂₈H₂₇FN₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35272-15-2
2-methylthiazole-4-carboxylic acid

: 1617505-01-7
2-[4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]aniline

: 1617505-28-8
C₂₈H₂₇FN₄O₂S

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; at 100 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm5006226

Reference yield:

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1617505-28-8
C₂₈H₂₇FN₄O₂S

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 50 h / 100 °C / Inert atmosphere; Sealed tube

2: zinc; ammonium chloride / methanol; ethyl acetate / 1 h / 20 °C / Inert atmosphere

3: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; sodium carbonate; ammonium chloride; triethylamine; zinc; In methanol; ethyl acetate; toluene; 3: |Curtius Rearrangement;
DOI:10.1021/jm5006226

Reference yield:

: 569688-69-3
(5-bromo-2-methoxyphenyl)hydrazine

: 1617505-28-8
C₂₈H₂₇FN₄O₂S

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / ethanol / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 0.75 h / 0 - 20 °C / Inert atmosphere

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 50 h / 100 °C / Inert atmosphere; Sealed tube

4.1: zinc; ammonium chloride / methanol; ethyl acetate / 1 h / 20 °C / Inert atmosphere

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; diphenyl phosphoryl azide; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; zinc; In methanol; ethanol; ethyl acetate; toluene; 1.1: |Fischer Indole Synthesis / 5.1: |Curtius Rearrangement;
DOI:10.1021/jm5006226