4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

Base Information

Chemical Name:4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole
CAS No.:1555701-57-9
Molecular Formula:C₁₇H₁₇BrN₂O₃
Molecular Weight:377.238
Hs Code.:

Synonyms:4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

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Chemical Property of 4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

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Technology Process of 4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

There total 2 articles about 4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 577-19-5
2-nitrophenyl bromide

: 1531844-07-1
4-bromo-7-methoxy-3,3-dimethylindoline

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 16h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm5006226

Reference yield:

: 569688-69-3
(5-bromo-2-methoxyphenyl)hydrazine

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / ethanol / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 0.75 h / 0 - 20 °C / Inert atmosphere

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; toluene; 1.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226

Reference yield: 98.0%

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1765-93-1
4-fluoroboronic acid

: 1617505-00-6
4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; at 100 ℃; for 50h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm5006226