1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide
• CAS No.: 287384-82-1
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.2
• Mol file: 287384-82-1.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid,ethyl ester,7-oxide;

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide

Chemical Property:

• PSA: 64.35000
• LogP: 1.45030

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide

There total 1 articles about 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester (221675-35-0) → ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate-7-oxide (287384-82-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 16h;

Reference yield: 100.0%

ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate-7-oxide (287384-82-1) → 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester (942920-55-0)

Guidance literature:

With tetrabutylammomium bromide; Methanesulfonic anhydride; In 1,2-dimethoxyethane; at 0 - 20 ℃; regioselective reaction;

DOI:10.1021/jm901870q

Reference yield:

ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate-7-oxide (287384-82-1) → 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (1234616-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetramethylammonium bromide; Methanesulfonic anhydride / chloroform / 16 h / 0 - 25 °C

2: water; sodium hydroxide / methanol / 6 h / 50 °C

With water; tetramethylammonium bromide; sodium hydroxide; Methanesulfonic anhydride; In methanol; chloroform;

upstream raw materials:

1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Downstream raw materials:

4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid