1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester
• CAS No.: 221675-35-0
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.20
• Hs Code.: 2933998090
• Mol file: 221675-35-0.mol

Synonyms:2-(Ethoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine;

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 355.936 °C at 760 mmHg
• PKA: 5.73±0.40(Predicted)
• Flash Point: 169.064 °C
• PSA: 54.98000
• Density: 1.272 g/cm³
• LogP: 1.73960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1H-Pyrrolo[2,3-B]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester

There total 14 articles about 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butyl) 2-ethyl 2-hydroxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1,2-dicarboxylate (287384-79-6) → 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester (221675-35-0)

Guidance literature:

With hydrogenchloride; at 20 - 50 ℃;

DOI:10.1016/j.ejmech.2014.08.062

Reference yield: 94.0%

ethanol (64-17-5) + 1-(phenyl-sulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (189089-90-5) → 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester (221675-35-0)

Guidance literature:

With sulfuric acid; for 20h; Reflux;

DOI:10.1016/j.ejmech.2015.12.023

Reference yield: 70.0%

→ 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester (221675-35-0)

Guidance literature:

upstream raw materials:

tert-butyl (3-methylpyridin-2-yl)carbamate

oxalic acid diethyl ester

1-(tert-butyl) 2-ethyl 2-hydroxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1,2-dicarboxylate

Ethyl isocyanoacetate

Downstream raw materials:

ethyl 1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

ethyl 1-(phenylmethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

ethyl 1-methyl-7-azaindole-2-carboxylate

C₁₀H₁₀N₂O₂