1H-Pyrrolo[2,3-b]pyridine-5-carboxylicacid,1-[(4-Methoxyphenyl)Methyl]-

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridine-5-carboxylicacid,1-[(4-Methoxyphenyl)Methyl]-
CAS No.:1201324-15-3
Molecular Formula:C16H14N2O3
Molecular Weight:282.299
Hs Code.:2933990090
Mol file:1201324-15-3.mol

Synonyms:1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid;4-methoxyphenyl-piperazinylketone;1-[(4-Methoxyphenyl)Carbonyl]Piperazine;(4-methoxyphenyl)(piperazin-1-yl)methanone;1-(4-Methoxybenzoyl)-piperazine;

Suppliers and Price of 1H-Pyrrolo[2,3-b]pyridine-5-carboxylicacid,1-[(4-Methoxyphenyl)Methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-5-carboxylicacid,1-[(4-Methoxyphenyl)Methyl]-

Chemical Property:

PSA：64.35000
LogP:2.79140

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-5-carboxylicacid,1-[(4-Methoxyphenyl)Methyl]-

There total 6 articles about 1H-Pyrrolo[2,3-b]pyridine-5-carboxylicacid,1-[(4-Methoxyphenyl)Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

: methyl 1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

: 1201324-15-3
1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 16h; Cooling with ice;
DOI:10.1016/j.bioorg.2021.105185

Reference yield: 25.0%

: 849067-96-5
1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

: 2746-25-0
p-Methoxybenzyl bromide

: 1201324-15-3
1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: 1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

p-Methoxybenzyl bromide; With potassium iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 517918-95-5
1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: 1201324-15-3
1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / ethanol / 16 h / 100 °C

2.1: thionyl chloride / 18 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 16 h / 20 °C

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 20 °C / Cooling with ice

With thionyl chloride; lithium hydroxide monohydrate; water; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2021.105185