(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

Base Information

Chemical Name:(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid
CAS No.:183503-17-5
Molecular Formula:C₂₃H₃₀N₄O₅S
Molecular Weight:474.581
Hs Code.:

(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

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Chemical Property of (S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

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Technology Process of (S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

There total 5 articles about (S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 183503-17-5
(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HOBt*H₂O, DCC / CH₂Cl₂

2: H₂, NaHCO₃ / 10percent Pd-C / tetrahydrofuran; H₂O / 24 h / 760 Torr

3: 1) HOBt*H₂O, DCC, 2) NEt₃ / 1) CH₂Cl₂, r.t., 2) CH₂Cl₂, r.t., overnight

4: TFA / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 29124-83-2
p-nitrobenzyl ester of 7-aminodeacetoxycephalosporanic acid

: 183503-17-5
(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HOBt*H₂O, DCC / CH₂Cl₂

2: H₂, NaHCO₃ / 10percent Pd-C / tetrahydrofuran; H₂O / 24 h / 760 Torr

3: 1) HOBt*H₂O, DCC, 2) NEt₃ / 1) CH₂Cl₂, r.t., 2) CH₂Cl₂, r.t., overnight

4: TFA / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 183503-12-0
(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 183503-17-5
(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, NaHCO₃ / 10percent Pd-C / tetrahydrofuran; H₂O / 24 h / 760 Torr

2: 1) HOBt*H₂O, DCC, 2) NEt₃ / 1) CH₂Cl₂, r.t., 2) CH₂Cl₂, r.t., overnight

3: TFA / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;