(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:183503-12-0
Molecular Formula:C₂₆H₃₄N₄O₈S
Molecular Weight:562.644
Hs Code.:

(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 1 articles about (6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 29124-83-2
p-nitrobenzyl ester of 7-aminodeacetoxycephalosporanic acid

: 183503-12-0
(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; Yield given;

Reference yield:

: 183503-12-0
(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: (S)-2-({(R)-2-[(R)-((S)-2-Amino-4-methyl-pentanoylamino)-methoxycarbonyl-methyl]-5-methyl-3,6-dihydro-2H-[1,3]thiazine-4-carbonyl}-amino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, NaHCO₃ / 10percent Pd-C / tetrahydrofuran; H₂O / 24 h / 760 Torr

2: 1) HOBt*H₂O, DCC, 2) NEt₃ / 1) CH₂Cl₂, r.t., 2) CH₂Cl₂, r.t., overnight

3: TFA / CH₂Cl₂ / 2 h / Ambient temperature

4: 48 h / 4 °C

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 183503-12-0
(6R,7R)-7-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 183503-17-5
(S)-2-{[(6R,7R)-7-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, NaHCO₃ / 10percent Pd-C / tetrahydrofuran; H₂O / 24 h / 760 Torr

2: 1) HOBt*H₂O, DCC, 2) NEt₃ / 1) CH₂Cl₂, r.t., 2) CH₂Cl₂, r.t., overnight

3: TFA / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;