6-Bromoquinolin-8-ol

Base Information

• Chemical Name: 6-Bromoquinolin-8-ol
• CAS No.: 139399-64-7
• Molecular Formula: C9H6BrNO
• Molecular Weight: 224.057
• European Community (EC) Number: 886-763-8
• NSC Number: 673454
• DSSTox Substance ID: DTXSID40327642
• Wikidata: Q82089597
• ChEMBL ID: CHEMBL1979811
• Mol file: 139399-64-7.mol

Synonyms:6-bromoquinolin-8-ol;139399-64-7;6-Bromo-8-quinolinol;NSC673454;8-Quinolinol, 6-bromo-;SCHEMBL3347624;CHEMBL1979811;AMY2122;DTXSID40327642;MFCD11878495;NSC-673454;SB72120;DS-11741;NCI60_026024;CS-0004310;FT-0760704;F52175;A922272

Chemical Property of 6-Bromoquinolin-8-ol

Chemical Property:

• Melting Point: 138-139 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 363.2 °C at 760 mmHg
• PKA: 4.25±0.30(Predicted)
• Flash Point: 173.5 °C
• PSA: 33.12000
• Density: 1.705 g/cm³
• LogP: 2.70290
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 222.96328
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-8-quinolinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CC(=CC(=C2N=C1)O)Br
• Uses: 6-Bromo-8-quinolinol is a useful intermediate in the preparation of 3,6-dibromo-8-quinolinol fungicides, which show fungicidal activity against Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides.

Technology Process of 6-Bromoquinolin-8-ol

There total 9 articles about 6-Bromoquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-bromo-8-methoxy-quinoline (103028-32-6) → 6-bromo-8-quinolinol (139399-64-7)

Guidance literature:

With hydrogen bromide; In water; at 130 ℃;

Reference yield: 72.0%

8-amino-6-bromoquinoline (57339-57-8) → 6-bromo-8-quinolinol (139399-64-7)

Guidance literature:

With sulfuric acid; In water; at 220 ℃; for 8h;

DOI:10.1007/BF01277632

Reference yield: 33.0%

2-Acetamido-5-bromophenyl Acetate (91715-77-4) → 6-bromo-8-quinolinol (139399-64-7)

Guidance literature:

With arsenic oxide; sulfuric acid; In glycerol; Heating;

DOI:10.1007/BF00823423

upstream raw materials:

6-bromo-8-methoxy-quinoline

2-Acetamido-5-bromophenyl Acetate

8-amino-6-bromoquinoline

4-bromo-2-methoxyaniline

Downstream raw materials:

2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol

6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-quinolin-8-ol

2,2-Dimethyl-propionic acid 6-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-quinolin-8-yl ester

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