6-broMo-8-Methoxyquinoline

Base Information

• Chemical Name: 6-broMo-8-Methoxyquinoline
• CAS No.: 103028-32-6
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.084
• Mol file: 103028-32-6.mol

Synonyms:6-bromo-8-methoxy-quinoline;2H-1-BENZOPYRAN,6-BROMO-8-METHOXY-3-NITRO-2-PHENYL;6-Brom-8-methoxy-chinolin;6-Bromo-8-methoxy-3-nitro-2-phenyl-2H-1-benzopyran;

Chemical Property of 6-broMo-8-Methoxyquinoline

Chemical Property:

• Boiling Point: 70-80 °C(Press: 24 Torr)
• PKA: 2.49±0.20(Predicted)
• PSA: 22.12000
• Density: 1.516±0.06 g/cm3(Predicted)
• LogP: 3.00590
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-?Bromo-?8-?methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-?Bromo-?8-?methoxyquinoline is a novel quinoline derivative which may also contain anticancer activity.

Technology Process of 6-broMo-8-Methoxyquinoline

There total 5 articles about 6-broMo-8-Methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2-methoxyaniline (59557-91-4) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 6-bromo-8-methoxy-quinoline (103028-32-6)

Guidance literature:

With sulfuric acid; sodium 3-nitrobenzenesulfonate; In water; at 0 - 120 ℃; for 24.5h; Inert atmosphere;

Reference yield: 44.0%

methanol (67-56-1) + 6,8-dibromo-1,2,3,4-tetrahydroquinoline (190843-73-3) → 8--bromo--6--methoxyquinoline (50488-36-3) + 6-bromo-8-methoxy-quinoline (103028-32-6)

Guidance literature:

methanol; 6,8-dibromo-1,2,3,4-tetrahydroquinoline; With copper(l) iodide; sodium; In benzene; at 150 ℃; for 20h; Inert atmosphere;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 80 ℃; for 40h; Inert atmosphere;

DOI:10.3906/kim-1301-30

Reference yield:

2-methoxy-phenylamine (90-04-0) → 6-bromo-8-methoxy-quinoline (103028-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 0 °C

2: sulfuric acid / water / Reflux

With sulfuric acid; bromine; acetic acid; In water;

DOI:10.1016/j.ejmech.2019.05.051

upstream raw materials:

4-bromo-2-methoxyaniline

glycerol

1,2,3,4-tetrahydroisoquinoline

methanol

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