Technology Process of Cyclopentanecarboxylic acid, 2-(4-bromobenzoyl)-, methyl ester, (1R,2R)-
There total 10 articles about Cyclopentanecarboxylic acid, 2-(4-bromobenzoyl)-, methyl ester, (1R,2R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
trans-(1R,2R)-2-(4-bromobenzoyl)cyclopentanecarboxylic acid; methyl iodide;
With
sodium hydrogencarbonate;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
With
hydrogenchloride;
In
DMF (N,N-dimethyl-formamide); water;
at 15 ℃;
for 1h;
pH=< 7;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C
2: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling
3: N-methyl-N-[(S)-1-phenylethyl]amine / Isopropyl acetate / 20 - 23 °C / Resolution of racemate
4: sodium hydrogencarbonate / N,N-dimethyl-formamide
With
N-methyl-N-[(S)-1-phenylethyl]amine; DBDMH; sodium hydrogencarbonate; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; methanol; Isopropyl acetate; water; N,N-dimethyl-formamide; acetonitrile;
2: Diketo Favorskii rearrangement;
DOI:10.1021/op900310v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aluminum (III) chloride
2: sodium hydroxide
3: N-methyl-N-[(S)-1-phenylethyl]amine / Isopropyl acetate / 20 - 23 °C / Resolution of racemate
4: sodium hydrogencarbonate / N,N-dimethyl-formamide
With
aluminum (III) chloride; N-methyl-N-[(S)-1-phenylethyl]amine; sodium hydrogencarbonate; sodium hydroxide;
In
Isopropyl acetate; N,N-dimethyl-formamide;
1: Friedel Crafts acylation;
DOI:10.1021/op900310v
