BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

Base Information

Chemical Name:BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-
CAS No.:918430-49-6
Molecular Formula:C₂₁H₂₉Cl₂FN₂O₂
Molecular Weight:431.378
Hs Code.:
Mol file:918430-49-6.mol

Synonyms:3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]ben;3,5-dichloro-N-((1-((2,2-diMethyltetrahydro-2H-pyran-4-yl)Methyl)-4-fluoropiperidin-4-yl)Methyl)benzaMide;3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]Benzamide;BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-;BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

Suppliers and Price of BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide 97%
250mg
$ 218.00

Crysdot
3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide 97%
1g
$ 545.00

Chemenu
3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide 95+%
1g
$ 514.00

Alichem
3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide
1g
$ 555.50

Alichem
3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide
250mg
$ 228.80

AK Scientific
3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
1g
$ 254.00

AK Scientific
3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
250mg
$ 142.00

AK Scientific
3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
100mg
$ 111.00

Total 6 raw suppliers

Chemical Property of BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

Chemical Property:

Vapor Pressure:1.6E-10mmHg at 25°C
Boiling Point:510.1°C at 760 mmHg
PKA:13.65±0.46(Predicted)
Flash Point:262.3°C
PSA：45.06000
Density:1.25g/cm³
LogP:5.24520
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Soluble in DMSO (10 mg/ml)

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description TTA-P2 (918430-49-6) is a potent (IC50 = 100 nM), specific, and reversible antagonist of T-type calcium channels with no activity at high voltage calcium channels.1,2 Highly potent in two animal models of pain in vivo.3

Technology Process of BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

There total 6 articles about BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918431-94-4
tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-fluoropiperidine-1-carboxylate

: 34941-21-4
2,2-dimethyltetrahydro-2H-pyran-4-carbaldehyde

: 918430-49-6,918431-87-5
3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide

Guidance literature:: tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-fluoropiperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 2h; macroporous resin

2,2-dimethyltetrahydro-2H-pyran-4-carbaldehyde; With methanol; MP-triacetoxyborohydride; In dichloromethane; for 14h;

Reference yield:

: 3,5-dichloro-N-(4-fluoro-piperidin-4-ylmethyl)-benzamide

: 34941-21-4
2,2-dimethyltetrahydro-2H-pyran-4-carbaldehyde

: 918430-49-6,918431-87-5
3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide

Guidance literature:: With macroporous polystyrene-bound triacetoxyborohydride; In dichloromethane;
DOI:10.1021/jm800419w

Reference yield:

: 918430-49-6,918431-87-5
3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide

: 918430-49-6,918431-87-5
(+)-N-((1-(3,3-dimethylbutyl)-4-fluoropiperidin-4-yl)methyl)-3-fluoro-5-(trifluoromethyl)benzamide hydrochloride

: 918430-49-6,918431-87-5
(-)-N-((1-(3,3-dimethylbutyl)-4-fluoropiperidin-4-yl)methyl)-3-fluoro-5-(trifluoromethyl)benzamide hydrochloride

Guidance literature:: 3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide; With trifluoroacetic acid; In ethanol; hexane; Resolution of racemate;

With sodium hydrogencarbonate; In water;

With hydrogenchloride; In diethyl ether; dichloromethane; Purification / work up;