3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Base Information

Chemical Name:3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
CAS No.:536760-29-9
Molecular Formula:C11H9ClN2O3
Molecular Weight:252.6538
Hs Code.:2933399090
European Community (EC) Number:823-671-9
UNII:XBH7777HDB
DSSTox Substance ID:DTXSID90470632
Wikidata:Q72518498
Mol file:536760-29-9.mol

Synonyms:536760-29-9;3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one;3-CHLORO-5,6-DIHYDRO-1-(4-NITROPHENYL)-2(1H)-PYRIDINONE;5-chloro-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;2(1H)-Pyridinone, 3-chloro-5,6-dihydro-1-(4-nitrophenyl)-;3-chloro-1-(4-nitrophenyl)-1,2,5,6-tetrahydropyridin-2-one;2(1H)-pyridine,3-chloro-5,6-dihydro-1-(4-nitrophenyl);XBH7777HDB;SCHEMBL8243895;DTXSID90470632;AMY36801;BCP11629;CS-M0373;MFCD18207128;AKOS015951085;FD10599;AC-26841;DS-16656;FT-0758197;EN300-1695798;A850072;J-512260;3-Chloro-5, 6-dihydro-1-(4-nitrophenyl)-2(1h)-pyridinone

Suppliers and Price of 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-?Chloro-?1-?(4-?nitrophenyl)?-?5,?6-?dihydropyridin-?2(1H)?-?one
1g
$ 550.00

TRC
3-?Chloro-?1-?(4-?nitrophenyl)?-?5,?6-?dihydropyridin-?2(1H)?-?one
500mg
$ 330.00

Crysdot
3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 95+%
100g
$ 297.00

ChemScene
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 99.31%
100g
$ 314.00

ChemScene
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 99.31%
10g
$ 58.00

ChemScene
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 99.31%
25g
$ 104.00

Chemenu
3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 95%
25g
$ 102.00

Chemenu
3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 95%
100g
$ 281.00

American Custom Chemicals Corporation
3-CHLORO-5,6-DIHYDRO-1-(4-NITROPHENYL)-2(1H)-PYRIDINONE 95.00%
1G
$ 1124.55

Ambeed
3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 95%
10g
$ 57.00

Total 123 raw suppliers

Chemical Property of 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Chemical Property:

Boiling Point:412.167 °C at 760 mmHg
PKA:-5.80±0.40(Predicted)
Flash Point:203.072 °C
PSA：66.13000
Density:1.456 g/cm³
LogP:3.04240
Storage Temp.:2-8°C
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:252.0301698
Heavy Atom Count:17
Complexity:356

Purity/Quality:

99% ^*data from raw suppliers

3-?Chloro-?1-?(4-?nitrophenyl)?-?5,?6-?dihydropyridin-?2(1H)?-?one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(C(=O)C(=C1)Cl)C2=CC=C(C=C2)[N+](=O)[O-]
Uses 3-?Chloro-?1-?(4-?nitrophenyl)?-?5,?6-?dihydropyridin-?2(1H)?-?one is used in the preparation of Apixaban intermediates and impurities.

Technology Process of 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

There total 4 articles about 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 881386-01-2
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

: 536760-29-9
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With lithium carbonate; lithium chloride; In N,N-dimethyl-formamide; at 105 ℃; for 4h; Green chemistry;

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 536760-29-9
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; tetrahydrofuran / 1 h / 20 °C / Green chemistry

1.2: 4 h / 20 °C / Green chemistry

2.1: phosphorus pentachloride / chlorobenzene / 2 h / 53 °C / Green chemistry

3.1: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry

With phosphorus pentachloride; lithium carbonate; lithium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 38560-30-4
1-(4-nitrophenyl)piperidine-2-one

: 536760-29-9
3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentachloride / chlorobenzene / 2 h / 53 °C / Green chemistry

2: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry

With phosphorus pentachloride; lithium carbonate; lithium chloride; In N,N-dimethyl-formamide; chlorobenzene;