CP466722

Base Information

• Chemical Name: CP466722
• CAS No.: 1080622-86-1
• Molecular Formula: C17H15N7O2
• Molecular Weight: 349.35
• Mol file: 1080622-86-1.mol

Synonyms:CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine

Chemical Property of CP466722

Chemical Property:

• Boiling Point: 642.3±65.0 °C(Predicted)
• PKA: 0.00±0.19(Predicted)
• PSA: 114.59000
• Density: 1.48
• LogP: 1.80200
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble0.5mg/mL, clear (warmed)

Purity/Quality:

99%, ^*data from raw suppliers

CP466722 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Description: CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).
• Uses: CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase

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