Chemical Products List

ATM / ATR inhibitor

ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) inhibitors are drugs that target the respective protein kinases, which are key regulators of the DNA damage response pathway. These kinases play crucial roles in sensing DNA damage, initiating repair mechanisms, and coordinating cell cycle checkpoints to maintain genomic stability. Inhibition of ATM or ATR prevents these kinases from activating downstream signaling pathways involved in DNA repair and cell cycle arrest. ATM inhibitors are primarily investigated for their potential in cancer therapy, where they aim to enhance the sensitivity of cancer cells to DNA-damaging treatments like chemotherapy and radiation therapy. ATR inhibitors, on the other hand, are being explored both as single agents and in combination therapies to selectively target cancer cells with defective DNA repair mechanisms, such as those deficient in BRCA genes.